84571-10-8Relevant articles and documents
Design, synthesis, and enzymatic characterization of quinazoline-based CYP1A2 inhibitors
Botello, Jordy F.,Corral, Pedro A.,Xing, Chengguo
, (2019)
Cytochrome P450 isozyme 1A2 (CYP1A2) is one main xenobiotic metabolizing enzyme in humans. It has been associated with the bioactivation of procarcinogens, including 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco specific and potent pulmo
A convenient one-pot procedure for the synthesis of 2-aryl quinazolines using active MnO2 as oxidant
Peng, Yi-Yuan,Zeng, Yuyun,Qiu, Ganyinsheng,Cai, Lisheng,Pike, Victor W.
experimental part, p. 1240 - 1245 (2010/11/18)
(Chemical Equation Presented) A variety of 2-aryl quinazolines were synthesized from the condensation of 2-aminobenzylamines and aryl aldehydes to form 2-aryl-1,2,3,4-tetrahydroquinazolines and subsequent oxidation of the intermediates with MnO2/sub
Synthesis of 3,1-benzoxazines and tetrahydroquinazolines from o-aminobenzyl alcohol and o-aminobenzyl amine - Semi-empirical MO calculations
Lessel
, p. 329 - 336 (2007/10/02)
o-Aminobenzyl alcohol (4) reacts with aldehydes and ketones to the 3,1-benzoxazines 20a/b and 22a/b, whereas the enamine derivatives 24a-c are formed from β-diketones. The isosteric o-amino-benzylamine (1) gives tetrahydroquinazolines 11a/b and 14b as het