84571-10-8Relevant academic research and scientific papers
Design, synthesis, and enzymatic characterization of quinazoline-based CYP1A2 inhibitors
Botello, Jordy F.,Corral, Pedro A.,Xing, Chengguo
, (2019)
Cytochrome P450 isozyme 1A2 (CYP1A2) is one main xenobiotic metabolizing enzyme in humans. It has been associated with the bioactivation of procarcinogens, including 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco specific and potent pulmo
Laccase-Based Oxidative Catalytic Systems for the Aerobic Aromatization of Tetrahydroquinazolines and Related N-Heterocyclic Compounds under Mild Conditions
Saadati, Shaghayegh,Ghorashi, Nadya,Rostami, Amin,Kobarfard, Farzad
, p. 4050 - 4057 (2018/08/21)
In this work, for the first time, laccase (metalloenzyme)/3,5-di-tert-butylcatechol (DTBC) as a new class of bioinspired quinone-based cooperative catalytic oxidation system and laccase/2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) catalyst system were used for the aerobic oxidative synthesis of 2-substituted quinazolines through cascade reaction of structurally divers aldehydes with 2-aminobenzylamine. The products were obtained in good to high yields in phosphate buffer (0.1 m, 12.5 mL, pH = 4.5) and acetonitrile (4 vol.-%) mixture as solvent at 45 °C. Other N-heterocycles are also successfully oxidized to their aromatic counterparts.
A convenient one-pot procedure for the synthesis of 2-aryl quinazolines using active MnO2 as oxidant
Peng, Yi-Yuan,Zeng, Yuyun,Qiu, Ganyinsheng,Cai, Lisheng,Pike, Victor W.
experimental part, p. 1240 - 1245 (2010/11/18)
(Chemical Equation Presented) A variety of 2-aryl quinazolines were synthesized from the condensation of 2-aminobenzylamines and aryl aldehydes to form 2-aryl-1,2,3,4-tetrahydroquinazolines and subsequent oxidation of the intermediates with MnO2/sub
Ring-chain tautomerism in 2-substituted 1,2,3,4-tetrahydroquinazolines A 1H, 13C and 15N NMR study
Sinkkonen, Jari,Zelenin, Kirill N.,Potapov, Abdul-Kadir A.,Lagoda, Igor V.,Alekseyev, Valeriy V.,Pihlaja, Kalevi
, p. 1939 - 1950 (2007/10/03)
In this work 32 1,2,3,4-tetrahydroquinazoline derivatives were synthesized by the reaction of 2-aminomethylaniline with aldehydes and ketones and their ring-chain tautomerism studied by 1H, 13C and 15N NMR spectroscopy. Th
Synthesis of 3,1-benzoxazines and tetrahydroquinazolines from o-aminobenzyl alcohol and o-aminobenzyl amine - Semi-empirical MO calculations
Lessel
, p. 329 - 336 (2007/10/02)
o-Aminobenzyl alcohol (4) reacts with aldehydes and ketones to the 3,1-benzoxazines 20a/b and 22a/b, whereas the enamine derivatives 24a-c are formed from β-diketones. The isosteric o-amino-benzylamine (1) gives tetrahydroquinazolines 11a/b and 14b as het
A new and convenient method for the preparation of 2-substituted quinazolines
Vanden Eynde,Godin,Mayence,Maquestiau,Anders
, p. 867 - 869 (2007/10/02)
Aldehydes, converted in situ into N-(1-chloroalkyl)pyridinium chlorides using thionyl chloride and pyridine, react with 2-aminobenzylamine, under mild conditions, to yield 1,2,3,4-tetrahydroquinazolines. The latter can be aromatized readily by treatment w
