845777-80-2Relevant academic research and scientific papers
Improving implant materials by coating with nonpeptidic, highly specific integrin ligands
Dahmen, Claudia,Auernheimer, Joerg,Meyer, Axel,Enderle, Anja,Goodman, Simon L.,Kessler, Horst
, p. 6649 - 6652 (2004)
Giving cells some stick: Osteoblast adhesion to titanium, a common material for implants, is stimulated by coating with an optimized and highly specific nonpeptidic ligand for the αvβ3 integrin (see picture). This new technology is advantageous to conventional coating by peptides or proteins in many practical aspects (selectivity and activity, stability against enzymatic degradation, sterilization, costs).
