845810-54-0Relevant academic research and scientific papers
"Polar patch" proteases as glycopeptiligases
Doores, Katie J.,Davis, Benjamin G.
, p. 168 - 170 (2005)
The strategy of combined site directed mutagenesis and chemical modification with polar prosthetic groups was used to broaden substrate specificity of proteases resulting in the first successful formation of glycopeptides through the use of glucoamino acid acyl donors in yields of up to 90%.
SAR-mediated similarity assessment of the property profile for new, silicon-based AChE/BChE inhibitors
Bak, Andrzej,Pizova, Hana,Kozik, Violetta,Vorcakova, Katarina,Kos, Jiri,Treml, Jakub,Odehnalova, Klara,Oravec, Michal,Imramovsky, Ales,Bobal, Pavel,Smolinski, Adam,Trávní?ek, Zdeněk,Jampilek, Josef
, (2019/11/11)
A set of 25 novel, silicon-based carbamate derivatives as potential acetyl-and butyrylcholinesterase (AChE/BChE) inhibitors was synthesized and characterized by their in vitro inhibition profiles and the selectivity indexes (SIs). The prepared compounds w
