84583-08-4Relevant articles and documents
Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases
Shankaran,Donnelly, Karla L.,Shah, Shrenik K.,Caldwell, Charles G.,Chen, Ping,Hagmann, William K.,MacCoss, Malcolm,Humes, John L.,Pacholok, Stephen G.,Kelly, Theresa M.,Grant, Stephan K.,Wong, Kenny K.
, p. 5907 - 5911 (2007/10/03)
The preparation and SAR of a series of iNOS inhibitors leading to the most potent compound, incorporating a (1,4)-5-imino thiazepane (R = n-Pr) is disclosed. A series of 3- and 5-imino analogs from oxazepane, thiazepane, and diazepane was prepared and eva
Phencyclidine derivatives, preparation method and pharmaceutical compositions containing same
-
, (2008/06/13)
The invention concerns novel phenylcyclidine derivatives with selective affinity for low affinity receptors, methods for preparing them, pharmaceutical compositions containing them and their use as protective agents for central or peripheral nervous system cells against acute or chronic degeneration, or as an anticonvulsant.
Thiomethylation of ketones by sodium sulphide and formaldehyde
Ulendeyeva,Bayeva,Lyapina,Shmakov,Galkin
, p. 177 - 186 (2007/10/03)
The thiomethylation of propanol, butanol, cyclohexanone and acetophenone with a mixture of formaldehyde and sodium sulphide proceeds at 20°C and normal pressure for 1-7 hr. It has been established that the reactivity of ketones increases in the order butanone-cyclohexanone-propanone-acetophenone. The conversion of sodium sulphide depends on its initial concentration, the nature of the ketone, and the presence in the reaction medium of sodium hydroxide and ethyl alcohol. It has been shown that the reaction proceeds with the preferential formation of keto- and diketosulphides.