845868-52-2Relevant academic research and scientific papers
Synthesis of Thieno, Pyrazolo and Isothiazolopyrimidine Derivatives Based on o-Mercaptoacetylpyrimidine Derivative
Ahmed, G. A.,Mostafa, H. Y.,Assy, M. G.,Mansor, Neven S.
, p. 11 - 25 (2007/10/03)
Mercaptopyrimidine 4 was prepared and transformed into methylmercaptopyrimidine 5. Compound 5 was transformed into pyrazolopyrimidine 6, and cinnamoylpyrimidine 7. Compound 4 reacted with halomethylene to produce thienopyrimidines 9, 10. Pyrimidine 4 was converted into pyrimidine derivative 12a, b, upon treatment with H2O2 in acetic acid and NaOH, respectively. Oxidation of 4 leads to disulfide 13. Heterocyclization of 4 using NaOCl in the presence of NaOH/NH4OH afforded isothiazolopyrimidine 15. Heterocyclization of 4 using aromatic aldehydes gives thiopyranopyrimidines 17a, b. Chlorination of 4 afforded chloropyrimidine 18, which was transformed into pyrrolopyrimidine 20 and pyrimidine derivatives 21a, b, c, d.
