845872-49-3

Basic information

• Product Name: 1-Benzothien-5-ylboronic acid
• Synonyms: 1-Benzothien-5-ylboronic acid;benzo[b]thiophen-5-ylboronic acid
• CAS NO: 845872-49-3
• Molecular Formula: C₈H₇BO₂S
• Molecular Weight: 178.01598
• Mol File: 845872-49-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 390.207°C at 760 mmHg
• Flash Point: 189.791°C
• Appearance: /
• Density: 1.355g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.669
• PKA: 8.39±0.30(Predicted)
• CAS DataBase Reference: 1-Benzothien-5-ylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzothien-5-ylboronic acid(845872-49-3)
• EPA Substance Registry System: 1-Benzothien-5-ylboronic acid(845872-49-3)

Safety Data

• Hazardous Substances Data: 845872-49-3(Hazardous Substances Data)

Usage

General Description

1-Benzothien-5-ylboronic acid is a chemical compound with the molecular formula C8H7BO2S. It is a boronic acid derivative containing a benzothiophene ring, and it is commonly used in organic synthesis and pharmaceutical research. It serves as a versatile building block for the construction of various organic molecules due to its ability to form stable boronate esters with cis-diol-containing substrates. 1-Benzothien-5-ylboronic acid has also been studied for its potential applications in the development of drugs and agrochemicals. Overall, 1-Benzothien-5-ylboronic acid is a valuable chemical that plays a key role in the synthesis of diverse organic compounds and has promising potential in various fields of research and development.

InChI:InChI=1/C8H7BO2S/c10-9(11)7-1-2-8-6(5-7)3-4-12-8/h1-5,10-11H

Upstream product

• 501945-71-7 2-(benzo[b]thiophen-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 4923-87-9 5-bromobenzo[b]thiophene 
• 13675-18-8 tetrahydroxydiboron 
• 67-56-1 methanol 
• 55124-35-1 diisopropylamine borane 

Downstream Products

• 1023591-94-7 C₂₂H₂₀N₄OS₂ 
• 107411-26-7 5-phenyl-1-benzothiophene 
• 1236313-24-8 3,5-diphenylbenzo[b]thiophene 

Relevant articles and documents

Transition-Metal-Free Borylation of Aryl Bromide Using a Simple Diboron Source

In this study, we developed a simple transition-metal-free borylation reaction of aryl bromides. Bis-boronic acid (BBA), was used, and the borylation reaction was performed using a simple procedure at a mild temperature. Under mild conditions, aryl bromides were converted to arylboronic acids directly without any deprotection steps and purified by conversion to trifluoroborate salts. The functional group tolerance was considerably high. The mechanism study suggested that this borylation reaction proceeds via a radical pathway.

Scalable, Metal- and Additive-Free, Photoinduced Borylation of Haloarenes and Quaternary Arylammonium Salts

We report herein a simple, metal- and additive-free, photoinduced borylation of haloarenes, including electron-rich fluoroarenes, as well as arylammonium salts directly to boronic acids. This borylation method has a broad scope and functional group tolerance. We show that it can be further extended to boronic esters and carried out on gram scale as well as under flow conditions.

Substituted Piperidines as Renin Inhibitors

Compounds of the general formula (I) in which the meanings of the substituents R1, R2, R3, R4, X, Z and n as stated in claim 1 have renin-inhibiting properties and can be used as medicines.