845872-49-3

Usage

General Description

1-Benzothien-5-ylboronic acid is a chemical compound with the molecular formula C8H7BO2S. It is a boronic acid derivative containing a benzothiophene ring, and it is commonly used in organic synthesis and pharmaceutical research. It serves as a versatile building block for the construction of various organic molecules due to its ability to form stable boronate esters with cis-diol-containing substrates. 1-Benzothien-5-ylboronic acid has also been studied for its potential applications in the development of drugs and agrochemicals. Overall, 1-Benzothien-5-ylboronic acid is a valuable chemical that plays a key role in the synthesis of diverse organic compounds and has promising potential in various fields of research and development.

InChI:InChI=1/C8H7BO2S/c10-9(11)7-1-2-8-6(5-7)3-4-12-8/h1-5,10-11H

Upstream product

• 501945-71-7 2-(benzo[b]thiophen-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 4923-87-9 5-bromobenzo[b]thiophene 
• 13675-18-8 tetrahydroxydiboron 
• 67-56-1 methanol 
• 55124-35-1 diisopropylamine borane 

Downstream Products

• 1023591-94-7 C₂₂H₂₀N₄OS₂ 
• 107411-26-7 5-phenyl-1-benzothiophene 
• 1236313-24-8 3,5-diphenylbenzo[b]thiophene 

Relevant academic research and scientific papers

Transition-Metal-Free Borylation of Aryl Bromide Using a Simple Diboron Source

In this study, we developed a simple transition-metal-free borylation reaction of aryl bromides. Bis-boronic acid (BBA), was used, and the borylation reaction was performed using a simple procedure at a mild temperature. Under mild conditions, aryl bromides were converted to arylboronic acids directly without any deprotection steps and purified by conversion to trifluoroborate salts. The functional group tolerance was considerably high. The mechanism study suggested that this borylation reaction proceeds via a radical pathway.

Magnesium promoted autocatalytic dehydrogenation of amine borane complexes: A reliable, non-cryogenic, scalable access to boronic acids

Owing to the unusual reactivity of dialkylamine-borane complexes, a methodology was developed to simply access boronic acids. The intrinsic instability of magnesium aminoborohydride was tweaked into a tandem dehydrogenation borylation sequence. Proceeding via an autocatalytic cycle, amineborane dehydrogenation was induced by a variety of Grignard reagents. Overall, addition of the organomagnesium species onto specially designed dialkylamine-borane complexes led to a variety of boronic acids in high yields. In addition, the reaction can be performed under Barbier conditions, on a large scale.

Scalable, Metal- and Additive-Free, Photoinduced Borylation of Haloarenes and Quaternary Arylammonium Salts

We report herein a simple, metal- and additive-free, photoinduced borylation of haloarenes, including electron-rich fluoroarenes, as well as arylammonium salts directly to boronic acids. This borylation method has a broad scope and functional group tolerance. We show that it can be further extended to boronic esters and carried out on gram scale as well as under flow conditions.

Compound with screw structure and organic electroluminescent device thereof

The invention provides an organic electroluminescent compound with a screw structure such as structural formula I, which has excellent thermal stability, high luminous efficiency, high optical purity and low driving voltage, can be used to make organic el

Substituted Piperidines as Renin Inhibitors

Compounds of the general formula (I) in which the meanings of the substituents R1, R2, R3, R4, X, Z and n as stated in claim 1 have renin-inhibiting properties and can be used as medicines.

Substituted piperidines as therapeutic compounds

Use of compounds of the general formula (1) and pharmaceutically acceptable salt thereof, in which R1, R2, R3, R4, W, X, Z and n have the definitions illustrated in detail in the description, as beta-secretase, cathepsin D, plasmepsin II and/or HIV protease inhibitors.

SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS

Compounds of the general formula (I) in which the meanings of the substituents R1, R2, R3, R4, W, X, Z and n as stated in Claim 1 have renin-inhibiting properties and can be used as medicines.