845883-08-1

Upstream product

• 125803-65-8 methyl (E)-3-<2RS,3RS)-2-(4-acetoxy-3-methoxyphenyl)-2,3-dihydro-7-methoxy-3-(methoxycarbonyl)-1-benzofuran-5-yl>-2-propenoate 
• 118799-80-7 (E)-methyl 3-<(2RS,3SR)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-3-methoxycarbonyl-1-benzofuran-5-yl>-1-propenoate 
• 162439-95-4 methyl (E)-3-<2-(4-acetoxy-3-methoxyphenyl)-7-methoxy-3-methoxycarbonylbenzofuran-5-yl>propenoate 

Downstream Products

• 1257866-63-9 2-(3-methoxy-4-hydroxyphenyl)-3-hydroxymethyl-5-(3-hydroxypropyl)-7-methoxybenzo[b]furan 
• 70610-22-9 2-(3-methoxy-4-hydroxyphenyl)-3-methoxycarbonyl-5-(3-hydroxypropyl)-7-methoxybenzo[b]furan 

Relevant academic research and scientific papers

Synthesis and cytotoxicity of novel benzofuran neolignan derivatives

A series of 10 related benzofuran neolignan derivatives were obtained by utilising a biomimetic reaction sequence involving oxidative dimerisation of methyl ferulate, followed by derivatisation reactions. The structures of the new compounds were confirmed by 1H NMR, elemental analysis, MS and IR. All compounds were evaluated for their cytotoxic potential against five human cancer cell lines (HL-60, SMMC-7721, A-549, SK-BR-3 and PAN-1) by the standard MTT method. The results showed that most of them exhibit potent cytotoxicity.

Antileishmanial activity, cytotoxicity and QSAR analysis of synthetic dihydrobenzofuran lignans and related benzofurans

A series of synthetic dihydrobenzofuran lignans and related benzofurans were evaluated for their cytotoxicity in a screening panel consisting of various human tumour cell lines, and for their antiprotozoal activity against L. donovani (axenic amastigotes)