845895-95-6

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
5,7-dichloropyrazolo[1,5-a]pyrimidine-3-carbonitrile is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows for the development of new compounds with potential therapeutic and pesticidal properties.
Used in Antifungal Applications:
5,7-dichloropyrazolo[1,5-a]pyrimidine-3-carbonitrile has been studied for its potential antifungal properties. It can be used as an active ingredient in antifungal agents to combat fungal infections in various settings.
Used in Anticancer Applications:
5,7-dichloropyrazolo[1,5-a]pyrimidine-3-carbonitrile has also been investigated for its potential anticancer properties. It can be used as a starting material for the development of new anticancer drugs, targeting specific cancer cells and inhibiting their growth and proliferation.
Used in Corrosion Inhibition:
5,7-dichloropyrazolo[1,5-a]pyrimidine-3-carbonitrile has been explored for its potential as a corrosion inhibitor. It can be used in various industries, such as oil and gas, to protect metal surfaces from corrosion and extend the lifespan of equipment.
Used in Fluorescent Sensor Applications:
Due to its unique structure, 5,7-dichloropyrazolo[1,5-a]pyrimidine-3-carbonitrile has been investigated for its potential as a fluorescent sensor. It can be used in analytical chemistry and environmental monitoring to detect specific substances or changes in conditions.

Upstream product

• 1310250-12-4 5,7-dihydroxypyrazolo[1,5-a]pyrimidine-3-carbonitrile 
• 16617-46-2 3-Amino-4-cyanopyrazole 
• 105-53-3 diethyl malonate 

Relevant academic research and scientific papers

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

CK2 INHIBITORS, COMPOSITIONS AND METHODS THEREOF

The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula (I), or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. For Formula (I) compounds R1, R2, R3, Ar and Z are as defined in the specification. The inventive Formula (I) compounds are inhibitors of CK2 and find utility in any number of therapeutic applications, including but not limited to treatment of proliferative disorders such as cancer, inflammation and immunological disorders.

3 -CYANO- 5 -ARYLAMINO-7 -CYCLOALKYLAMINOPYRROLO [1, 5 -A] PYRIMIDINE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS

The invention relates to chemical compounds of Formula (I): or a salt thereof. In some embodiments, the invention relates to inhibitors of CK2. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein and their use in the prevention and treatment of CK2-related conditions and diseases, e.g., cancer.

Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: Discovery and in vivo activity of selective pyrazolo[1,5- a ]pyrimidine inhibitors using a focused library and structure-based optimization approach

A novel class of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) inhibitors was discovered through screening a kinase-focused library. A homology model of MAPKAP-K2 was generated and used to guide the initial SAR studies and to rationalize the observed selectivity over CDK2. An X-ray crystal structure of a compound from the active series bound to crystalline MAPKAP-K2 confirmed the predicted binding mode. This has enabled the discovery of a series of pyrazolo[1,5-a]pyrimidine derivatives showing good in vitro cellular potency as anti-TNF-α agents and in vivo efficacy in a mouse model of endotoxin shock.