84591-28-6

Upstream product

• 71573-93-8 1-(4-chlorophenyl)-3-methyl-butan-1-one 
• 108-90-7 chlorobenzene 

Downstream Products

• 51445-44-4 1-(4-chlorophenyl)-2-hydroxy-3-methyl-1-butanone 
• 51445-43-3 2-Acetoxy-1-(p-chlorphenyl)-3-methyl-butanon⁽¹⁾ 
• 169295-50-5 2-(α-chloroacetoxy)-1-(4-chlorophenyl)-3-methyl-1-butanone 

Relevant academic research and scientific papers

COMPOUND FOR INHIBITING TYROSINE KINASE ACTIVITY OF DDR2 PROTEIN

A new furopyrimidine compound, their pharmaceutically acceptable salt, and a tyrosine kinase activity inhibitor. The furopyrimidine compound is a compound defined by chemical formula 1, 2, 3 or 4, on their precursor, and can exist as a form of free base or in an acid-addition salt. Since the furopyrimidine compound has an effect of inhibiting activity of DDR2 tyrosine kinase, it can be used in treating illnesses caused by the DDR2 tyrosine kinase activity such as hepatocirrhosis, rheumatoid arthritis or cancer.

Resolution of Secondary α-Ketoalcohols Catalyzed by Lipase and Inversioon of Stereochemistry

Several α-ketoalcohols of synthetic value were resolved using lipase as a catalyst.Lipoprotein lipase (LPL) provided the best rate of hydrolysis and kinetic differentiation.One of these optically pure α-ketoalcohol was converted to (S)-ibuprofen in good optical purity.The stereospecific inversion of (R)-alcohol to (S)-alcohol is described.Key Words Enzymatic resolution; α-Ketoalcohol; (S)-Ibuprofen