845965-29-9

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 172947-80-7 (2S,4R)-1-ethyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 845965-33-5 1-ethyl 2-methyl (2S,4R)-4-(tetrahydro-2H-pyran-2-yloxy)pyrrolidine-1,2-dicarboxylate 

Downstream Products

• 845965-31-3 (6R,7aS)-6-methoxy-1,1-diphenyltetrahydropyrrolo[1,2-c]oxazol-3(1H)-one 
• 845965-30-2 (6R,7aS)-6-Hydroxy-1,1-diphenyl-tetrahydro-pyrrolo[1,2-c]oxazol-3-one 

Relevant academic research and scientific papers

Fluorinated chiral secondary amines as catalysts for epoxidation of olefins with oxone

(Chemical Equation Presented) We have synthesized a series of chiral cyclic secondary amines having different substitution patterns and have screened them as catalysts for the asymmetric epoxidation of olefins using Oxone. The highest enantiomeric excess (61%) occurred for the epoxidation of 1-phenylcyclohexene catalyzed by a secondary amine bearing a fluorine atom at the β-position relative to the amino center. Our experimental results provide further support to the notion that the amine plays a dual role - as a phase transfer catalyst and an Oxone activator - in these epoxidation reactions. The slightly acidic reaction conditions we employed in this work obviate the need to preform ammonium salts, which are the actual catalysts that mediate the epoxidations.