845965-30-2

Upstream product

• 100-58-3 phenylmagnesium bromide 
• 172947-80-7 (2S,4R)-1-ethyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 344791-02-2 (2S,4R)-4-hydroxy-2-(1-hydroxy-1,1-diphenylmethyl)pyrroline-1-carboxylic acid tert-butyl ester 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 83487-17-6 (2S,4R)-(-)-N-methyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid methyl ester 
• 845965-33-5 1-ethyl 2-methyl (2S,4R)-4-(tetrahydro-2H-pyran-2-yloxy)pyrrolidine-1,2-dicarboxylate 
• 845965-29-9 (6R,7aS)-1,1-Diphenyl-6-(tetrahydro-pyran-2-yloxy)-tetrahydro-pyrrolo[1,2-c]oxazol-3-one 

Downstream Products

• 176747-44-7 (2S,4R)-4-hydroxy-α,α-diphenyl-2-pyrrolidinemethanol 

Relevant academic research and scientific papers

Polymer-Supported Chiral Cis-Disubstituted Pyrrolidine Catalysts and Their Application to Batch and Continuous-Flow Systems

Polymer-supported cis-pyrrolidine catalysts were developed that allowed for high enantioselectivity and diastereoselectivity compared with those obtained from common trans-pyrrolidine catalysts. Not only configurational but also polymeric effects contribute to the high diastereoselectivity and enantioselectivity. Polymer catalysts were also successfully applied in a continuous-flow process. Acceleration of the reaction rate, an increase in diastereoselectivity, and an improvement in durability were observed in continuous-flow operation compared with the batch system.

A new organocatalytic concept for asymmetric -alkylation of aldehydes

The organocatalytic asymmetric -alkylation of aldehydes by 1,6-conjugated addition of enamines to p-quinone methides is described. Employing a newly developed class of chiral secondary amine catalysts,-diarylmethine-substituted aldehydes with two contiguo

NOVEL NI COMPLEX AND ITS DERIVATIVES, PRODUCING METHOD, AND THE USE THEREOF AS AN ANTIOXIDANT

The present invention relates to a novel nickel complex and its derivatives, which mimic the active site of Ni-containing superoxide dismutase (NiSOD). The five-coordinate Ni(II) and Ni(III) complexes or their derivatives, and six-coordinate derivatives have the following structures of formula (I) and (II): The nickel complexes and their derivatives of the invention act as anti-oxidants or free radical scavengers. The invented nickel complexes can be used in the preparation of medicines, health foods or cosmetics for human, animals and plants, or can be used in environmental or soil protection.

Fluorinated chiral secondary amines as catalysts for epoxidation of olefins with oxone

(Chemical Equation Presented) We have synthesized a series of chiral cyclic secondary amines having different substitution patterns and have screened them as catalysts for the asymmetric epoxidation of olefins using Oxone. The highest enantiomeric excess (61%) occurred for the epoxidation of 1-phenylcyclohexene catalyzed by a secondary amine bearing a fluorine atom at the β-position relative to the amino center. Our experimental results provide further support to the notion that the amine plays a dual role - as a phase transfer catalyst and an Oxone activator - in these epoxidation reactions. The slightly acidic reaction conditions we employed in this work obviate the need to preform ammonium salts, which are the actual catalysts that mediate the epoxidations.