846031-09-2

Upstream product

• 34837-55-3 Phenylselenyl bromide 
• 96552-61-3 2-ethyl-6-methoxy-3,5-dimethyl-4H-pyran-4-one 

Downstream Products

• 59795-94-7 (+/-)-spectinabilin 
• 846571-47-9 (±)-aureothin 
• 856859-87-5 (+/-)-2-((Z)-4-((2Z,4E,6E)-2-bromo-4,6-dimethyl-7-(4-nitrophenyl)hepta-2,4,6-trienylidene)-tetrahydrofuran-2-yl)-6-methoxy-3,5-dimethyl-4H-pyran-4-one 
• 856859-85-3 (+/-)-2-((E)-4-((2Z,4E,6E)-2-bromo-4,6-dimethyl-7-(4-nitrophenyl)hepta-2,4,6-trienylidene)-tetrahydrofuran-2-yl)-6-methoxy-3,5-dimethyl-4H-pyran-4-one 
• 857086-91-0 (+/-)-2-methoxy-3,5-dimethyl-6-((E)-4-((2E,4E,6E)-2,4,6-trimethyl-7-(4-nitrophenyl)hepta-2,4,6-trienylidene)-tetrahydrofuran-2-yl)-4H-pyran-4-one 
• 846031-14-9 (+/-)-2-((Z)-4-((Z)-2-bromo-3-(4-nitrophenyl)allylidene)-tetrahydrofuran-2-yl)-6-methoxy-3,5-dimethyl-4H-pyran-4-one 
• 846031-16-1 (+/-)-aureothamine 

Relevant academic research and scientific papers

The biomimetic synthesis of SNF4435C and SNF4435D, and the total synthesis of the polyene metabolites aureothin, N-acetyl-aureothamine and spectinabilin

Full details of the biomimetic conversion of polyene metabolite spectinabilin (5) into the isomeric natural products SNF4435C (1) and SNF4435D (2) by a cascade of E/Z-isomerizations and electrocyclizations are reported. Additionally, short total syntheses

A short total synthesis of aureothin and N-acetylaureothamine

(Chemical Equation Presented) The total synthesis of the nitrophenyl pyrones, (±)-aureothin and (±)-N-acetylaureothamine, starting from known 2-ethyl-6-methoxy-3,5-dimethyl-4H-pyran-4-one are described. The key steps involved in the synthesis are the cons