857086-91-0

Upstream product

• 856859-85-3 (+/-)-2-((E)-4-((2Z,4E,6E)-2-bromo-4,6-dimethyl-7-(4-nitrophenyl)hepta-2,4,6-trienylidene)-tetrahydrofuran-2-yl)-6-methoxy-3,5-dimethyl-4H-pyran-4-one 
• 544-97-8 dimethyl zinc(II) 
• 846031-10-5 2-methoxy-3,5-dimethyl-6-vinyl-4H-pyran-4-one 
• 846031-08-1 (+/-)-2-methoxy-3,5-dimethyl-6-(4-methylenetetrahydrofuran-2-yl)-4H-pyran-4-one 
• 846031-09-2 (+/-)-2-methoxy-3,5-dimethyl-6-(1-(phenylselenyl)ethyl)-4H-pyran-4-one 
• 856859-84-2 1-((1E,3E)-6,6-dibromo-2,4-dimethylhexa-1,3,5-trienyl)-4-nitrobenzene 
• 846031-12-7 (+/-)-2-methoxy-3,5-dimethyl-6-(4-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylene)-tetrahydrofuran-2-yl)-4H-pyran-4-one 
• 59488-84-5 (2E,4E)-2,4-dimethyl-5-(p-nitrophenyl)pentan-2,4-dienal 
• 96552-61-3 2-ethyl-6-methoxy-3,5-dimethyl-4H-pyran-4-one 
• 159213-40-8 6-methoxy-3,5-dimethyl-4-oxo-4H-pyran-2-carbaldehyde 

Relevant academic research and scientific papers

The biomimetic synthesis of SNF4435C and SNF4435D, and the total synthesis of the polyene metabolites aureothin, N-acetyl-aureothamine and spectinabilin

Full details of the biomimetic conversion of polyene metabolite spectinabilin (5) into the isomeric natural products SNF4435C (1) and SNF4435D (2) by a cascade of E/Z-isomerizations and electrocyclizations are reported. Additionally, short total syntheses

Fancy bioisosteres: Synthesis, SAR, and pharmacological investigations of novel nonaromatic dopamine D3 receptor ligands

Structural variations of the lead compound FAUC 88 led to dopaminergic enynes with an extended π-system when Pd-catalyzed cross coupling reactions were employed for the key reaction steps. The dienyne 9b displayed substantial affinity for the dopamine rec

The total synthesis of spectinabilin and its biomimetic conversion to SNF4435C and SNF4435D

(Chemical Equation Presented) A short synthesis of (±)-spectinabilin via a trans-selective Suzuki coupling and subsequent Negishi-type methylation, and its biomimetic conversion to (±)-SNF4435C and (±)-SNF4435D is described.