846037-03-4 Usage
Explanation
The molecular formula represents the number of atoms of each element present in a molecule. In this case, the compound has 10 carbon (C), 6 hydrogen (H), 1 fluorine (F), 3 nitrogen (N), and 1 oxygen (O) atoms.
Explanation
Naphthyridine derivatives are a group of chemical compounds that contain a naphthyridine ring, which is a fused six-membered nitrogen-containing ring system. 1,6-Naphthyridin-2(1H)-one, 7-fluoro- belongs to this class.
Explanation
The fluorine atom is attached to the seventh position of the naphthyridine ring, which can influence the compound's reactivity, stability, and biological activity.
Explanation
Due to its biological activities, such as inhibition of kinases and enzymes, 1,6-Naphthyridin-2(1H)-one, 7-fluoro- has potential pharmaceutical applications and can be further explored for drug development.
Explanation
The compound exhibits biological activities that involve inhibiting the function of certain kinases and enzymes, which can be relevant for the treatment of various diseases.
Explanation
The structure and properties of 1,6-Naphthyridin-2(1H)-one, 7-fluoro- make it a useful tool for researchers in the fields of medicinal chemistry and drug discovery, as it can be used to study the interactions between molecules and their biological targets.
Explanation
The naphthyridine ring is a key structural feature of 1,6-Naphthyridin-2(1H)-one, 7-fluoro-, consisting of a fused six-membered ring with a nitrogen atom incorporated into the structure.
Explanation
The molecular weight is the sum of the atomic weights of all the atoms in the molecule. For 1,6-Naphthyridin-2(1H)-one, 7-fluoro-, the molecular weight is approximately 211.17 g/mol.
Explanation
The solubility of 1,6-Naphthyridin-2(1H)-one, 7-fluoro- will depend on the specific solvent used, as it can vary for different chemical compounds. Generally, naphthyridine derivatives may have varying solubility profiles in polar and non-polar solvents.
Explanation
As with many organic compounds, 1,6-Naphthyridin-2(1H)-one, 7-fluoromay be sensitive to factors such as light, heat, and moisture, which can affect its stability and shelf life. Proper storage conditions should be maintained to preserve the compound's integrity.
Class
Naphthyridine derivatives
Fluorine Attachment
Seventh position of the naphthyridine ring
Pharmaceutical Applications
Potential candidate for drug development
Biological Activities
Inhibition of kinases and enzymes
Utility in Research
Medicinal chemistry and drug discovery
Chemical Structure
Fused six-membered nitrogen-containing ring system
Molecular Weight
211.17 g/mol
Solubility
Solvent-dependent
Stability
May be sensitive to light, heat, and moisture
Check Digit Verification of cas no
The CAS Registry Mumber 846037-03-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,6,0,3 and 7 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 846037-03:
(8*8)+(7*4)+(6*6)+(5*0)+(4*3)+(3*7)+(2*0)+(1*3)=164
164 % 10 = 4
So 846037-03-4 is a valid CAS Registry Number.
846037-03-4Relevant articles and documents
Discovery of PF-00217830: Aryl piperazine napthyridinones as D2 partial agonists for schizophrenia and bipolar disorder
Johnson, Douglas S.,Choi, Chung,Fay, Lorraine K.,Favor, David A.,Repine, Joseph T.,White, Andrew D.,Akunne, Hyacinth C.,Fitzgerald, Lawrence,Nicholls, Kim,Snyder, Bradley J.,Whetzel, Steven Z.,Zhang, Liming,Serpa, Kevin A.
, p. 2621 - 2625 (2011/06/20)
The synthesis and structure-activity relationship (SAR) of a novel series of aryl piperazine napthyridinone D2 partial agonists is described. Our goal was to optimize the affinities for the D2, 5-HT2A and 5-HT1A receptors, such that the D2/5-HT2A ratio was greater than 5 to ensure maximal occupancy of these receptors when the D2 occupancy reached efficacious levels. This strategy led to identification of PF-00217830 (2) with robust inhibition of sLMA (MED = 0.3 mg/kg) and DOI-induced head twitches in rats (31% and 78% at 0.3 and 1 mg/kg) with no catalepsy observed at the highest dose tested (10 mg/kg).
