846049-69-2

Upstream product

• 5233-04-5 3,5-dichloro-1,2-phenylenediamine 
• 82326-55-4 4,6-dichloro-1H-benzo[d]imidazole 

Downstream Products

• 846049-65-8 2-[(4-bromo-phenyl)-piperidin-4-ylidene-methyl]-4,6-dichloro-1H-benzoimidazole 
• 846048-99-5 4'-[(4,6-dichloro-1H-benzoimidazol-2-yl)-piperidin-4-ylidene-methyl]-biphenyl-3-carbonitrile 

Relevant academic research and scientific papers

Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists

Biaryl urea lead compound 1 was discovered earlier in our MCH antagonist program. Novel benzimidazole analogues with increased chemical stability, devoid of the potential carcinogenic liability associated with a biarylamine moiety, were synthesized and evaluated to be potent MCH R1 antagonists. Two compounds in this series have demonstrated in vivo efficacy in a rodent obesity model.

2-Substituted benzimidazole derivatives as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders

The present invention discloses compounds of formula I wherein Ar, X, R1 and R11 are herein defined, said compounds being novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In