5233-04-5

Basic information

• Product Name: CHEMBRDG-BB 5366312
• Synonyms: CHEMBRDG-BB 5366312;(2-AMINO-3,5-DICHLOROPHENYL)AMINE;(2-amino-3,5-dichlorophenyl)amine(SALTDATA: FREE);3,5-Dichloro-1,2-phenylene-diaMine;3,5-Dichloro-1,2-diaMinobenzene;3,5-Dichloro-1,2-diaMinobenzene 97%;3,5-Dichlorobenzene-1,2-diamine;3,5-Dichloro-1,2-benzenediamine
• CAS NO: 5233-04-5
• Molecular Formula: C₆H₆Cl₂N₂
• Molecular Weight: 177.03
• Mol File: 5233-04-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 60-65°C
• Boiling Point: 318°C at 760 mmHg
• Flash Point: 146.1°C
• Appearance: /
• Density: 1.501g/cm³
• Vapor Pressure: 0.000372mmHg at 25°C
• Refractive Index: 1.679
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.05±0.10(Predicted)
• CAS DataBase Reference: CHEMBRDG-BB 5366312(CAS DataBase Reference)
• NIST Chemistry Reference: CHEMBRDG-BB 5366312(5233-04-5)
• EPA Substance Registry System: CHEMBRDG-BB 5366312(5233-04-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 5233-04-5(Hazardous Substances Data)

Usage

General Description

CHEMBRDG-BB 5366312 is a chemical compound with the molecular formula C22H24N4O2S. It is a member of the benzamide class of compounds and is an inhibitor of the voltage-gated sodium channel Nav1.7. This makes it a potential candidate for the treatment of pain and other neurological disorders. It has been studied for its potential use in the management of chronic pain, including diabetic neuropathy and neuropathic pain. Additionally, it has also shown potential as a treatment for inflammatory and neuropathic pain in various preclinical models. Overall, CHEMBRDG-BB 5366312 is a promising compound with potential therapeutic applications in the treatment of pain and neurological conditions.

InChI:InChI=1/C6H6Cl2N2/c7-3-1-4(8)6(10)5(9)2-3/h1-2H,9-10H2

Upstream product

• 103-84-4 Acetanilid 
• 2683-43-4 2,4-dichloro-6-nitroaniline 
• 626-43-7 3,5-Dichloroaniline 
• 6975-29-7 N-(2,4-dichlorophenyl)acetamide 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 5233-05-6 4,6-dichloro-2-methyl-1H-benzimidazole 
• 99515-70-5 4,6-dichloro-2-(2,4-dichloro-phenyl)-1⁽³⁾H-benzimidazole 
• 16407-65-1 5,7-dichlorobenzo-2,1,3-thiadiazole 
• 69950-82-9 C₁₆H₂₆Cl₂N₄O₆P₂S₂ 
• 107933-54-0 6,8-Dichloro-3-(4-nitro-phenyl)-1,2-dihydro-quinoxaline 
• 107933-53-9 5,7-Dichloro-3-(4-nitro-phenyl)-1,2-dihydro-quinoxaline 
• 107933-47-1 6,8-Dichloro-3-p-tolyl-1,2-dihydro-quinoxaline 
• 107933-46-0 5,7-Dichloro-3-p-tolyl-1,2-dihydro-quinoxaline 
• 107933-49-3 6,8-Dichloro-3-(4-methoxy-phenyl)-1,2-dihydro-quinoxaline 
• 107933-48-2 5,7-Dichloro-3-(4-methoxy-phenyl)-1,2-dihydro-quinoxaline 
• 107487-76-3 2-(5,7-Dichloro-3-phenyl-1,2-dihydro-quinoxalin-2-yl)-1-phenyl-ethanone 
• 82326-55-4 4,6-dichloro-1H-benzo[d]imidazole 
• 708978-04-5 4,6-dichloro-2-phenyl-1H-benzimidazole 

Relevant articles and documents

Preparation method of 3, 5-dichloroo-phenylenediamine

The invention relates to an industrial preparation method of 3, 5-dichloroo-phenylenediamine, which comprises the following steps of: by using 3, 5-dichloroaniline as an initial raw material, carryingout protection, nitrification, deprotection and reduction reaction to synthesize the 3, 5-dichloroo-phenylenediamine. The 3, 5-dichloroo-phenylenediamine obtained in the process is a brown solid, thepurity is 97.5%, the conversion rate of raw materials in each step reaches 100%, the total yield of the whole process reaches 52.7%, 3, 5-dichloroaniline is used as an initial raw material, the positioning property is good, the impurity is few, and the purification is easy.

Highly selective hydrogenation of aromatic chloronitro compounds to aromatic chloroamines with ionic-liquid-like copolymer stabilized platinum nanocatalysts in ionic liquids

Platinum nanoparticles (PtNPs stabilized by an ionic-liquid-like-copolymer (IP) immobilized in various ionic liquids (ILs)) effectively catalyze the selective hydrogenation of aromatic chloronitro compounds to aromatic chloroamines, a reaction of considerable commercial significance. The preparation of 2,4-dichloro-3-aminophenol (DAP) has been primarily studied due to its important industrial applications. DAP is usually prepared from 2,4-dichloro-3-nitrophenol (DNP) by reduction with hydrogen using Ni- or Pt-based catalysts. Compared to reactions in molecular (organic) solvents, the ILs system provides superior selectivity with functionalized ILs containing an alcohol group demonstrating the best recyclability, and ultimately achieving a turnover number of 2025 which is 750 fold higher than Raney nickel catalyst. A universal catalyst-ionic liquid system for the conversion of aromatic chloronitro compounds to aromatic chloroamines was also established. TEM, XPS, IR spectroscopy were used to characterize the morphology of the nanocatalysts allowing their structure to be correlated to their activity.

QUINOXALINE COMPOUNDS AND THEIR PREPARATION AND USE

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