84619-59-0Relevant articles and documents
Enantioselective hydroxylation of nitroalkenes: An organocatalytic approach
Diner, Peter,Nielsen, Martin,Bertelsen, Soren,Niess, Barbara,Jorgensen, Karl Anker
, p. 3646 - 3648 (2008/03/12)
An easy hydroxylation of aliphatic nitroalkenes in high yields and enantioselectivities is catalysed by bifunctional thiourea-cinchona alkaloids giving access to optically active nitroalcohols and aminoalcohols as final products. The Royal Society of Chem
Synthesis of Homochiral Amino Alcohols, Aziridines and Diamines via Homochiral Cyclic Sulphites
Lohray, Braj B.,Ahuja, Jaimala R.
, p. 95 - 97 (2007/10/02)
Vicinal diols react with thionyl chloride to give 1,2-cyclic sulphites in quantitative yield, which undergo facile ring opening by lithium azide in dimethylformamide to yield azido alcohols and the latter in turn have been stereoselectively transformed into amino alcohols, aziridines and diamines.
A Convenient Route to (R)-α-Hydroxy Carboxylic Acids and (2R)-1-Amino-2-alkanols from (R)-Cyanohydrins
Ziegler, Thomas,Hoersch, Brigitte,Effenberger, Franz
, p. 575 - 578 (2007/10/02)
(R)-Cyanohydrins, prepared in good to excellent yields with high optical purity by enzyme-catalyzed addition of hydrogen cyanide to aldehydes in organic solvents, are hydrolyzed with concentrated hydrochloric acid at ambient temperature, usually in very high yield, without any trace of racemization to give (R)-α-hydroxy carboxylic acids.Likewise, no racemization is observed by direct reduction of the (R)-cyanohydrins with lithium aluminium hydride to give (2R)-1-amino-2-alkanols.
Importance of the Aromatic Ring in Adrenergic Amines. 7. Comparison of the Stereoselectivity of Norepinephrine N-Methyltransferase for Aromatic vs. Nonaromatic Substrates and Inhibitors
Rafferty, Michael F.,Wilson, David S.,Monn, James A.,Krass, Polina,Borchardt, Ronald T.,Grunewald, Gary L.
, p. 1198 - 1204 (2007/10/02)
Some nonaromatic analogues of amphetamine and α-methylbenzylamine were prepared and evaluated as competitive inhibitors of norepinephrine N-methyltranspherase (NMT).All of the nonaromatic analogues were significantly more active than their aromatic counte
