84637-43-4

Basic information

• Product Name: 1,2-Benzisoxazol-3-ylacetyl chloride
• Synonyms: 1,2-Benzisoxazol-3-ylacetyl chloride
• CAS NO: 84637-43-4
• Molecular Formula: C9H6ClNO2
• Molecular Weight: 195.61
• Mol File: 84637-43-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2-Benzisoxazol-3-ylacetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzisoxazol-3-ylacetyl chloride(84637-43-4)
• EPA Substance Registry System: 1,2-Benzisoxazol-3-ylacetyl chloride(84637-43-4)

Safety Data

• Hazardous Substances Data: 84637-43-4(Hazardous Substances Data)

Usage

Type of compound

Acetyl chloride derivative of 1,2-benzisoxazole

Heterocyclic compound

Contains both nitrogen and oxygen

Common use

Reagent in organic synthesis

Application

Preparation of pharmaceuticals and agrochemicals

Ability

To form amide and ester derivatives

Versatility

Acts as a building block in chemical reactions

Reactivity

Towards nucleophiles

Utility

Formation of various functionalized compounds

Industry use

Widely used in pharmaceutical and agrochemical industries

Upstream product

• 4865-84-3 2-(benzo[d]isoxazol-3-yl)acetic acid 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 

Downstream Products

• 84637-57-0 (E)-2-Benzo[d]isoxazol-3-yl-3-hydroxy-5-(2-hydroxy-phenyl)-5-oxo-pent-2-enoic acid methyl ester 
• 84637-58-1 (E)-2-Benzo[d]isoxazol-3-yl-3,5-dihydroxy-5-(2-hydroxy-phenyl)-pent-2-enoic acid methyl ester 
• 84637-56-9 (2E,4E)-5-Amino-2-benzo[d]isoxazol-3-yl-3-hydroxy-5-(2-hydroxy-phenyl)-penta-2,4-dienoic acid methyl ester 
• 84637-55-8 (2E,4Z)-5-Amino-2-benzo[d]isoxazol-3-yl-3-hydroxy-5-(2-hydroxy-phenyl)-penta-2,4-dienoic acid methyl ester 

Relevant articles and documents

AUXIN-LIKE ACTIVITY OF 1,2-BENZISOXAZOLE-3-ALKANOIC ACIDS

A series of benzisoxazole-alkanoic acids, differing in the length of the side-chain, have been synthesized and their activity tested on pea stem elongation, flax root growth and shoot regeneration from tomato cotyledon explants.All compounds had little or no effect on cell elongation or root growth, but a stimulating effect on shoot induction in vitro, thus showing that their activity, like that of 1,2-benzisoxazole acetic acid. is partly independent of the side-chain and is linked to the structure of the benzisoxazole ring. - Key words: 1,2-Benzisoxazole-3-alkanoic acids; auxin-like activity; pea stem elongation; flax root growth; in vitro shoot generation.

Facile preparation of protected benzylic and heteroarylmethyl amines via room temperature Curtius rearrangement

A step-wise, room temperature procedure for acyl azide formation and the subsequent Curtius rearrangement of phenyl and heteroaryl acetic acids is described. We have developed a protocol for room temperature Curtius rearrangement in MeOH or CHCl3 that provides an improvement over standard conditions, avoiding the use of additives or heat. This room temperature optimization of the Curtius rearrangement prevents the formation of side products often observed with benzylic acids, allowing access to a variety of benzylic and heteroarylmethyl amines.