84643-53-8

Basic information

• Product Name: (2-hydroxyethyl)(2-hydroxyhexadecyl)dimethylammonium chloride
• Synonyms: (2-hydroxyethyl)(2-hydroxyhexadecyl)dimethylammonium chloride;HYDROXYCETYL HYDROXYETHYL DIMONIUM CHLORIDE;1-Hexadecanaminium, 2-hydroxy-N-(2-hydroxyethyl)-N,N-dimethyl-, chloride;Dimethyl-N-(2-hydroxyethyl)-N-(2-hydroxyhexadecyl) -ammoniumchlorid;hydroxycetyl hydroxyethyl dimonium chloride,hydroxycetyl hydroxyethyl dimethyl;HYDROXYCETYL HYDROXYETHYL DIMONIUM CHLORIDE, HYDROXYCETYL HYDROXYETHYL DIMETHYL AMMONIUM CHLORIDE;cetyldimethyl-2-hydroxy-N-(2-hydroxyethyl)ammonium chlor.;Einecs 283-450-2
• CAS NO: 84643-53-8
• Molecular Formula: C18H37Cl2O2
• Molecular Weight: 356.39118
• EINECS: 283-450-2
• Mol File: 84643-53-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-hydroxyethyl)(2-hydroxyhexadecyl)dimethylammonium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2-hydroxyethyl)(2-hydroxyhexadecyl)dimethylammonium chloride(84643-53-8)
• EPA Substance Registry System: (2-hydroxyethyl)(2-hydroxyhexadecyl)dimethylammonium chloride(84643-53-8)

Safety Data

• RIDADR: 1759
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 84643-53-8(Hazardous Substances Data)

Usage

General Description

The chemical compound (2-hydroxyethyl)(2-hydroxyhexadecyl)dimethylammonium chloride, also known as dihydroxyethyl cocodimethyl ammonium chloride, is a quaternary ammonium compound used as a cationic surfactant and fabric softener in various personal care and cleaning products. It is derived from coconut oil and is water soluble, making it an effective emulsifier and conditioning agent for hair and skin care products. However, it is also known to be a skin irritant and can cause allergic reactions in some individuals, so it is important to use this chemical with caution and follow proper safety guidelines. Additionally, it is important to note that this compound may have environmental impacts and should be used and disposed of responsibly.

InChI:InChI=1/C20H44NO2.ClH/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-20(23)19-21(2,3)17-18-22;/h20,22-23H,4-19H2,1-3H3;1H/q+1;/p-1

Upstream product

• 7320-37-8 1,2-epoxyhexadecane 
• 108-01-0 2-(N,N-dimethylamino)ethanol 

Relevant articles and documents

A structure-activity study of spermicidal and anti-HIV properties of hydroxylated cationic surfactants

The syntheses of 2-hydroxy-N-(2-hydroxyethyl)-N,N-dimethylhexadecan-1-aminium chloride [1(16)Cl] and iodide [1(16)I], 2-hydroxy-N,N,N-trimethylhexadecan-1-aminium chloride (6), N-(2-hydroxyethyl)-N,N-dimethylhexadecan-1-aminium chloride (8), N,N-bis(2-hydroxyethyl)-N-methylhexadecan-1-aminium chloride (11), and 2-hydroxy-N-(2-hydroxyethyl)-N,N-dimethyl-4-oxahexadecan-1-aminium chloride (14) are reported along with the critical micelle concentrations (cmcs), as measured by conductivity at 25°C, of 1(16)Cl, 1(16)I, 6, 8, 11, and N,N,N-trimethylhexadecan-1-aminium chloride (12). All compounds display spermicidal and virucidal activity. A plot of minimum effective concentration (MEC) in the Sander-Cramer spermicidal assay and cmc shows that 1(16)Cl and 6 have the best spermicidal activity and highest cmcs. Compounds 8, 11, and 1(16)Cl are the most active at 0.05 mg mL-1 against cell-free and cell-associated virus. In conclusion, 1(16)Cl shows the best combination of dual activity against sperm and HIV; it is a promising candidate for further preclinical studies as a topical, contraceptive microbicide.