84647-23-4

Basic information

• Product Name: 2-(benzyloxy)-6-methylnicotinonitrile
• Synonyms: 2-(benzyloxy)-6-methylnicotinonitrile
• CAS NO: 84647-23-4
• Molecular Weight: 224.262
• Mol File: 84647-23-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(benzyloxy)-6-methylnicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(benzyloxy)-6-methylnicotinonitrile(84647-23-4)
• EPA Substance Registry System: 2-(benzyloxy)-6-methylnicotinonitrile(84647-23-4)

Safety Data

• Hazardous Substances Data: 84647-23-4(Hazardous Substances Data)

Upstream product

• 28900-10-9 2-chloro-6-methylnicotinonitrile 
• 20194-18-7 sodium phenyl-methanolate 
• 100-44-7 benzyl chloride 
• 4241-27-4 1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile 

Downstream Products

• 1005485-68-6 2-Benzyloxy-6-methylnicotinaldehyde 

Relevant articles and documents

Zinc (II)-mediated selective O-benzylation of 2-Oxo-1,2-dihydropyridines systems

The selective O-benzylation of 2-oxo-1,2-dihydropyridines plays a critical role in organic synthesis of natural products and biological active molecules. Herein we report a novel ternary system of ZnO, ZnCl2 and N,N-diisopropylethylamine (DIEA), that is highly effective for selective O-benzylation of 2-oxo-1,2-dihydropyridines using abundant substituted benzyl halides and related substituted 2-oxo-1,2-dihydropyridines compounds. This process allows access to a variety of O-benzyl products under mild reaction conditions, which are important synthetic intermediates in the protection of functional groups, and represents a new method toward the development for the O-benzylation of 2-oxo-1,2-dihydropyridines.