84661-32-5

Basic information

• Product Name: 5-amino-3-methyl-4-isoxazolecarboxylic acid 4'-chlorophenyl amide
• Synonyms: 5-amino-3-methyl-4-isoxazolecarboxylic acid 4'-chlorophenyl amide
• CAS NO: 84661-32-5
• Molecular Weight: 251.672
• Mol File: 84661-32-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-amino-3-methyl-4-isoxazolecarboxylic acid 4'-chlorophenyl amide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-3-methyl-4-isoxazolecarboxylic acid 4'-chlorophenyl amide(84661-32-5)
• EPA Substance Registry System: 5-amino-3-methyl-4-isoxazolecarboxylic acid 4'-chlorophenyl amide(84661-32-5)

Safety Data

• Hazardous Substances Data: 84661-32-5(Hazardous Substances Data)

Upstream product

• 106-47-8 4-chloro-aniline 
• 17722-17-7 N-(4-chlorophenyl)-2-cyanoacetamide 
• 84661-50-7 5-amino-3-methyl-1,2-oxazole-4-carboxylic acid 

Downstream Products

• 201145-94-0 3-Methyl-5-[2,2,2-trichloro-eth-(E)-ylideneamino]-isoxazole-4-carboxylic acid (4-chloro-phenyl)-amide 
• 201146-04-5 5-{[1-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-meth-(E)-ylidene]-amino}-3-methyl-isoxazole-4-carboxylic acid (4-chloro-phenyl)-amide 
• 201146-10-3 3-Methyl-5-[N-(5-methyl-pyridin-2-yl)-formimidoylamino]-isoxazole-4-carboxylic acid (4-chloro-phenyl)-amide 
• 201145-98-4 N-[4-(4-Chloro-phenylcarbamoyl)-3-methyl-isoxazol-5-yl]-formimidic acid methyl ester 

Relevant articles and documents

Synthesis of some substituted isoxazolo [5,4-d] pyrimidine-4(5H)-ones and their biological evaluation

Substituted anilines vk'ere condensed Wiih ethyl cyanoacetate in xylene to get corresponding 2-cyano-N-phenylacetamides 1a-1h, which upon reaction with sodium bicarbonate and acetic anhydride gave corresponding compounds 2-cyano-3-hydroxy-N-phenylbut-2-enamides 2a-2h, which further upon reaction with hydroxyl amine hydrochloride in methanol yielded corresponding 5-amino-3-methyl-N-phenylisoxazole-4-carboxamides 3a-3h. 3a-3h when treated with acetic anhydride and triethyl orthoformate, gave substituted isoxazolo [5,4-d] pyrimidin-4 (5H)-ones 4a-4h.

Synthesis, immunomodulating effects and structure-activity relationships of new N-phenyl-5-amino-3-methylisoxazole-4-carboxamides

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