5-amino-3-methyl-4-isoxazolecarboxylic acid 4'-chlorophenyl amide

Base Information

• Chemical Name: 5-amino-3-methyl-4-isoxazolecarboxylic acid 4'-chlorophenyl amide
• CAS No.: 84661-32-5
• Molecular Formula: C₁₁H₁₀ClN₃O₂
• Molecular Weight: 251.672

Synonyms:5-amino-3-methyl-4-isoxazolecarboxylic acid 4'-chlorophenyl amide

Chemical Property of 5-amino-3-methyl-4-isoxazolecarboxylic acid 4'-chlorophenyl amide

Chemical Property:

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Technology Process of 5-amino-3-methyl-4-isoxazolecarboxylic acid 4'-chlorophenyl amide

There total 5 articles about 5-amino-3-methyl-4-isoxazolecarboxylic acid 4'-chlorophenyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C11H9ClN2O2 → 5-amino-3-methyl-4-isoxazolecarboxylic acid 4'-chlorophenyl amide (84661-32-5)

Guidance literature:

With hydroxylamine hydrochloride; In methanol; for 16h; Reflux;

Reference yield: 87.0%

5-amino-3-methyl-1,2-oxazole-4-carboxylic acid (84661-50-7) + 4-chloro-aniline (106-47-8) → 5-amino-3-methyl-4-isoxazolecarboxylic acid 4'-chlorophenyl amide (84661-32-5)

Guidance literature:

With dicyclohexyl-carbodiimide; In dimethyl sulfoxide; for 10h; Ambient temperature;

DOI:10.1016/S0223-5234(99)80035-X

Reference yield:

2-cyano-3-ethoxy-but-2-enoic acid (4-chloro-phenyl)-amide → 5-amino-3-methyl-4-isoxazolecarboxylic acid 4'-chlorophenyl amide (84661-32-5)

Guidance literature:

With potassium hydroxide; hydroxylamine hydrochloride; In methanol; at 60 ℃;

DOI:10.1016/j.bmcl.2006.11.087

upstream raw materials:

5-amino-3-methyl-1,2-oxazole-4-carboxylic acid

4-chloro-aniline

N-(4-chlorophenyl)-2-cyanoacetamide

Downstream raw materials:

3-Methyl-5-[2,2,2-trichloro-eth-(E)-ylideneamino]-isoxazole-4-carboxylic acid (4-chloro-phenyl)-amide

5-{[1-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-meth-(E)-ylidene]-amino}-3-methyl-isoxazole-4-carboxylic acid (4-chloro-phenyl)-amide

3-Methyl-5-[N-(5-methyl-pyridin-2-yl)-formimidoylamino]-isoxazole-4-carboxylic acid (4-chloro-phenyl)-amide

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