84675-71-8

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 50392-57-9 dimethyl [(3,4-dimethoxyphenyl)(hydroxy)methyl]phosphonate 
• 2398-37-0 3-methoxyphenyl bromide 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 91-16-7 1,2-dimethoxybenzene 
• 6834-42-0 3-methoxyphenylacetic acid chloride 
• 591-31-1 3-methoxy-benzaldehyde 

Downstream Products

• 102520-87-6 Acetic acid 2-acetoxy-5-[(E)-2-(3-acetoxy-phenyl)-1-phenyl-but-1-enyl]-phenyl ester 
• 102520-86-5 Acetic acid 2-acetoxy-5-[(Z)-2-(3-acetoxy-phenyl)-1-phenyl-but-1-enyl]-phenyl ester 
• 477339-87-0 2-bromo-1-(3,4-dimethoxyphenyl)-2-(3-methoxyphenyl)ethanone 
• 84675-74-1 1-(3,4-Dimethoxy-phenyl)-2-(3-methoxy-phenyl)-butan-1-one 
• 239448-51-2 4-(3,4-dimethoxyphenyl)-5-(3-methoxyphenyl)-2-methylthiazole 

Relevant academic research and scientific papers

Towards a facile synthesis of triarylethanones: Palladium-catalyzed arylation of ketone enolates under homogeneous and heterogeneous conditions

The palladium-catalyzed regioselective α-monoarylation of deoxybenzoins and α,α-diarylation of acetophenones provides general, efficient access to 1,2,2-triarylethanones. After a comprehensive search for suitable experimental conditions to optimize such transformations, both reactions are alternatively conducted by means of either commercially available polymer-anchored catalysts or a very simple homogeneous catalytic system, thus avoiding the use of complex ligands. In addition, the synthesis of deoxybenzoins employing polymer-supported fibrous palladium catalysts is reported for the first time, and the excellent catalyst recycling properties suggest applicability to industrial purposes.

A simple route to new phenanthro- and phenanthroid-fused thiazoles by a PIFA-mediated (hetero)biaryl coupling reaction

An application of the PIFA-mediated [PIFA: phenyliodine(III) bis(trifluoroacetate) biaryl coupling reaction is presented and extended to the formation of heterobiaryl connections. A preliminary study of the scope and limitations of this procedure was carried out in the synthesis of phenanthroids 11 from a series of phenethyl-substituted heterocycles 10, It was observed that in some cases a competitive dimerization process took place. It was also found that the coupling step could be efficiently extended to a larger number of examples if an aromatic ring were situated fused to the 1,2-diarylethane skeleton, as in 23 and 30. The synthesis of a series of 4,5-diarylthiazoles 23a-g was therefore carried out to explore the electronic requirements and the regioselectivity of the PIFA-mediated non-phenolic coupling reaction. When the same procedure was applied to aryl-heteroarylthiazoles 30, a series of phenanthroid-fused thiazoles 31 was obtained in good overall yields. To the best of our knowledge, no oxidative aryl-heteroaryl coupling reaction of this type had previously been reported. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.

REGIOSPECIFICALLY SUBSTITUTED DEOXIBENZOINS BY HORNER CONDENSATION OF AROMATIC ALDEHYDES WITH O-PROTECTED α-ARYL-α-HYDROXYMETHANEPHOSPHONATES

Dimethyl-α-aryl-α-hydroxymethanephosphonates, prepared by addition of dimethyl phosphite to the appropriate aromatic aldehyde, Ar-CHO, have been protected at oxygen by reaction with 3,4-dihydro-2H-pyran catalyzed by p-toluenesulphonic acid and condensed w