84689-20-3Relevant articles and documents
AN IMPROVED PROCESS FOR THE PREPARATION OF LAMOTRIGINE
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Page/Page column 3; 5, (2009/07/03)
The present invention relates to an improved process for the preparation of Lamotrigine (I) comprising a step of cyclizing 2-(2,3-Dichlorophenyl)-2-(guanidinoimino)acetonitrile(III) in the presence of an alcohol and an acid.
Process for preparing substituted Benzoyl Cyanide Amidinohydrazones
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, (2008/06/13)
The present invention provides a process for preparing a compound of the general formula (I):wherein R1to R5are independently selected from hydrogen, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl or C1-6alkoxy, all optionally substituted by one or more of halogen, hydroxy and aryl groups, as well as being independently selected from amino, mono- or disubstituted amino, alkenyloxy, acyl, acyloxy, cyano, nitro, aryl and alkylthio groups, which process comprises reacting a compound of the general formula (II):wherein R1to R5are as defined in formula (I), with aminoguanidine bicarbonate in a mixture of a water-soluble solvent and polyphosphoric acid.