84689-20-3

Basic information

• Product Name: 2-(2,3-Dichlorophenyl)-2-guanidinyliminoacetonitrile
• Synonyms: N-(alpha-cyno-2,3-dichlorobenzylideneimino)guanidine;2-(2,3-Dichlorphenyl)-2-(guanidinylimino)acetonitrile;(2,3-Dichloro-Phenyl)guanidyliMino Acetonitril;Hydrazine carboxidazole 2-[cyano (2,3-dichlorophenyl)]Methane OR Hydrazine CarboxiMidaMide 2-[Cyano (2,3-Dichlorophenyl)] Methane OR 2-Cyano [(2,3-[Dichlorophenyl) Methylene] hydrazine carboxiMidaMide;LaMotrigine EP IMpurity-C;HydrazinecarboxiMidaMide,2-[cyano(2,3-dichlorophenyl)Methylene]-;2-(2,3-DICHLOROPHENYL)-2-(GUANIDINIMINO)ACETONITRILE;2-(2,3-DICHLOROPHENYL)-2-GUANIDINYLIMINOACETONITRILE
• CAS NO: 84689-20-3
• Molecular Formula: C₉H₇Cl₂N₅
• Molecular Weight: 256.09
• EINECS: 1533716-785-6
• Product Categories: Amines;Aromatics;Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 84689-20-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 176-178 °C
• Boiling Point: 445.6 °C at 760 mmHg
• Flash Point: 223.3 °C
• Appearance: /
• Density: 1.52 g/cm³
• Vapor Pressure: 3.91E-08mmHg at 25°C
• Refractive Index: 1.669
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: DMSO (Slightly, Heated), Methanol (Slightly)
• PKA: 4.06±0.70(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: 2-(2,3-Dichlorophenyl)-2-guanidinyliminoacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,3-Dichlorophenyl)-2-guanidinyliminoacetonitrile(84689-20-3)
• EPA Substance Registry System: 2-(2,3-Dichlorophenyl)-2-guanidinyliminoacetonitrile(84689-20-3)

Safety Data

• Hazardous Substances Data: 84689-20-3(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

Different sources of media describe the Uses of 84689-20-3 differently. You can refer to the following data:
1. 2-(2,3-Dichlorphenyl)-2-(guanidinylimino)acetonitrile (Lamotrigine EP Impurity C) is an intermediate in the synthesis of the drug Lamotrigine (L173250).
2. An intermediate in the synthesis of the drug Lamotrigine (L173250).

InChI:InChI=1/C9H7Cl2N5/c10-6-3-1-2-5(8(6)11)7(4-12)15-16-9(13)14/h1-3H,(H4,13,14,16)/b15-7+

Upstream product

• 77668-42-9 2,3-dichlorobenzoyl cyanide 
• 2582-30-1 aminoguanidine bicarbonate 
• 79-17-4 aminoguanidine 

Downstream Products

• 84057-84-1 lamotrigine 

Relevant articles and documents

AN IMPROVED PROCESS FOR THE PREPARATION OF LAMOTRIGINE

The present invention relates to an improved process for the preparation of Lamotrigine (I) comprising a step of cyclizing 2-(2,3-Dichlorophenyl)-2-(guanidinoimino)acetonitrile(III) in the presence of an alcohol and an acid.

Process for preparing substituted Benzoyl Cyanide Amidinohydrazones

The present invention provides a process for preparing a compound of the general formula (I):wherein R1to R5are independently selected from hydrogen, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl or C1-6alkoxy, all optionally substituted by one or more of halogen, hydroxy and aryl groups, as well as being independently selected from amino, mono- or disubstituted amino, alkenyloxy, acyl, acyloxy, cyano, nitro, aryl and alkylthio groups, which process comprises reacting a compound of the general formula (II):wherein R1to R5are as defined in formula (I), with aminoguanidine bicarbonate in a mixture of a water-soluble solvent and polyphosphoric acid.