84689-47-4Relevant articles and documents
Recent advances in selective syntheses of 6- and 7-substituted pteridines
Murata, Shizuaki,Kiguchi, Kenji,Sugimoto, Takashi
, p. 1255 - 1274 (1998)
Novel regioselective methods for construction of biologically important pteridines which contain carbon substituents on the 6- or 7-position using pteridine ring-forming cyclocondensations, nucleophilic substitution reactions, and radical reactions are reviewed.
Pteridines, LXXII. - Synthesis and Properties of 6- and 7-Amino-1,3-dimethyllumazines
Steppan, Heinz,Hammer, Joachim,Baur, Ralph,Gottlieb, Raphael,Pfleiderer, Wolfgang
, p. 2135 - 2145 (2007/10/02)
The synthesis of 6- and 7-amino-, -methylamino-, and -dimethylamino-1,3-dimethyllumazines (2-4 and 12-14) is described.The nucleophilic displacement reaction proceeds easily with the 7-halo-1,3-dimethyllumazines 10, 11 whereas the amidation of 6-hydroxy-1,3-dimethyllumazine (1) with phenyl diamidophosphates is recommended for the formation of 6-amino derivatives. 6-Amino-1,3-dimethyllumazine (2) is synthesized best from 6-chloro-1,3-dimethyllumazine (7) via the 6-hydrazino derivative 5 and subsequent reduction.From pKa value determinations and UV absorption spectra of the cationic and neutral forms can be seen that protonation takes place in both series at N-5.The physical properties of the newly synthesized compounds are discussed.