847062-13-9

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 185023-34-1 5-carboethoxy-6-methyl-4-(4-methylphenyl)-1H-pyrimidin-2-thione 
• 74-88-4 methyl iodide 
• 141-97-9 ethyl acetoacetate 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1236204-31-1 ethyl 4-methyl-2-(methylthio)-6-p-tolylpyrimidine-5-carboxylate 
• 1412900-77-6 ethyl 3-(5-bromo-benzofuran-2-carbonyl)-7-methyl-1-phenyl-5-p-tolyl-1,5-dihydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylate 
• 1117816-29-1 C₃₁H₂₅ClN₄O₄ 

Relevant academic research and scientific papers

Novel pyrimidinic selenourea induces DNA damage, cell cycle arrest, and apoptosis in human breast carcinoma

Novel pyrimidinic selenoureas were synthesized and evaluated against tumour and normal cell lines. Among these, the compound named 3j initially showed relevant cytotoxicity and selectivity for tumour cells. Three analogues of 3j were designed and synthesi

Mild and efficient oxidative aromatization of 4-substituted-1,4- dihydropyrimidines using (diacetoxyiodo)benzene

(Chemical Equation Presented) 4-Alkyl or aryl-1,4-dihydropyrimidines were readily oxidized by (diacetoxyiodo)benzene under mild reaction conditions to the corresponding pyrimidine derivatives in good to excellent yields.

Synthesis and anti-hypertensive activity of some dihydropyrimidines

Wide range of biological activities are associated with 1,4-dihydropyridines/pyrimidines, individually or in combination. In view of the synthesis of various 6-methyl-4-substitutedphenyl-2-thioxo-1,2,3,4- tetrahydropyrimidine-5-carboxylic acid ethyl esters and 6-methyl-4-substituted phenyl-2-S-alkyl(benzyl)-1,4-dihydropyrimidine-5-carboxylic acid ethyl esters was undertaken for synthesizing biologically active molecules with improved activity, lesser toxicity with undesirable side effects in clinical use. The synthesized compounds have been tested for anti-hypertensive activity and show some new results about the structure-activity relationship contrary to an earlier reports.