185023-34-1

Basic information

• Product Name: ethyl 6-methyl-2-thioxo-4-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• Synonyms: ethyl 6-methyl-2-thioxo-4-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• CAS NO: 185023-34-1
• Molecular Formula: C₁₅H₁₈N₂O₂S
• Molecular Weight: 290.38062
• Mol File: 185023-34-1.mol
• Article Data: 106

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 6-methyl-2-thioxo-4-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 6-methyl-2-thioxo-4-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate(185023-34-1)
• EPA Substance Registry System: ethyl 6-methyl-2-thioxo-4-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate(185023-34-1)

Safety Data

• Hazardous Substances Data: 185023-34-1(Hazardous Substances Data)

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 17356-08-0 thiourea 
• 2929-93-3 p-tolylmethylenediacetate 
• 589-18-4 4-Methylbenzyl alcohol 
• 1147550-11-5 ammonium thiocyanate 

Downstream Products

• 635292-04-5 ethyl 3-amino-5-(4-methylphenyl)-2-cyano-7-methyl-5H-thiazolo[a-2,3]pyrimidine-6-carboxylate 
• 324072-09-5 ethyl 5-(4-methylphenyl)-7-methyl-2-(4-chlorophenyl)methylene-3-oxo-2,3-dihydro-5H-thiazolo[a-2,3]pyrimidine-6-carboxylate 
• 347322-42-3 5-(4-methylphenyl)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester 
• 1420034-56-5 ethyl 7-methyl-3-phenyl-5-(p-tolyl)-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 52693-87-5 4-methylbenzaldehyde hydrazone 
• 17356-08-0 thiourea 
• 57-13-6 urea 
• 132712-71-1 5-hydroxy-3-methylpyrazole 

Relevant articles and documents

Supramolecular synthesis of 3,4-dihydropyrimidine-2(1H)-one/thiones under neat conditions

An efficient solvent free method for the synthesis of various 3,4-dihydropyrimidin-2(1H)-one/thiones in excellent yields using sulfonated β-cyclodextrine as recyclable catalyst is described. Sulfonated β-cyclodextrine was found to be efficient, recyclable

Microwave-assisted synthesis of dihydropyrimidin-2(1H)-ones using graphite supported lanthanum chloride as a mild and efficient catalyst

Graphite supported lanthanum chloride efficiently catalyzes the three-component coupling of β-ketoesters, aldehydes and urea/thiourea to afford corresponding dihydropyrimidinones in good yields under microwave irradiation.

Amino acid ionic liquid-catalyzed synthesis, anti-Leishmania activity, molecular docking, molecular dynamic simulation, and ADME study of 3,4-dihydropyrimidin-2(1H)-(thio)ones

The synthesis of 3,4-dihydropyrimidin-2(1H)-(thio)one (DHPM) derivatives involving aromatic aldehyde, β-ketoesters and urea/thiourea using prolinium hydrogen sulfate (ProHSO4) as a catalyst has been studied. A variety of DHPM derivatives were o

Aiding the versatility of simple ammonium ionic liquids by the synthesis of bioactive 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives

Simple ammonium ionic liquids [ILs] are efficient, green, environmentally friendly catalysts in promoting the Biginelli condensation reaction, Hantzsch reaction and Niementowski reaction to afford 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives respectively by eliminating the need for harmful volatile organic solvents. These [ILs] are air and water stable, easy to prepare and cost-effective. The effects of the anions and cations present in [IL] on reactions were investigated. The results clearly indicated that the Biginelli condensation reaction, Hantzsch reaction and Niementowski reaction were heavily influenced by the acidity of [IL], and among various ammonium ionic liquids, [Et3NH][HSO4] showed the best catalytic activity. Furthermore, [IL] could be easily separated and reused with a slight loss of its activity. This technique provided a good alternative way for the industrial synthesis of 1,2,3,4-tetrahydropyrimidinones, 2-aminothiazoles and quinazolinones. The present processes are eco-friendly methods for the synthesis of these derivatives authenticated by several green parameters, namely,E-factor, process mass intensity, reaction mass efficiency, atom economy, and carbon efficiency.