185023-34-1

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 17356-08-0 thiourea 
• 589-18-4 4-Methylbenzyl alcohol 
• 1147550-11-5 ammonium thiocyanate 
• 2929-93-3 p-tolylmethylenediacetate 

Downstream Products

• 635292-04-5 ethyl 3-amino-5-(4-methylphenyl)-2-cyano-7-methyl-5H-thiazolo[a-2,3]pyrimidine-6-carboxylate 
• 324072-09-5 ethyl 5-(4-methylphenyl)-7-methyl-2-(4-chlorophenyl)methylene-3-oxo-2,3-dihydro-5H-thiazolo[a-2,3]pyrimidine-6-carboxylate 
• 847062-13-9 ethyl 6-methyl-2-(methylthio)-4-p-tolyl-1,4-dihydropyrimidine-5-carboxylate 
• 347322-42-3 5-(4-methylphenyl)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester 
• 1034918-27-8 6-ethoxycarbonyl-7-methyl-5-(4-methylphenyl)-5H-thiazolo[3,2-a]pyrimidine 
• 1117816-29-1 C₃₁H₂₅ClN₄O₄ 
• 1296205-31-6 ethyl 1-(ethoxymethyl)-4-methyl-2-thioxo-6-p-tolyl-1,2,3,6-tetrahydropyrimidine-5-carboxylate 
• 1301742-01-7 C₃₀H₃₂N₄O₄S 
• 1420034-56-5 ethyl 7-methyl-3-phenyl-5-(p-tolyl)-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1421829-31-3 ethyl 2-(4-bromophenylthio)-4-methyl-6-p-tolylpyrimidin-5-carboxylate 
• 1421829-19-7 ethyl 4-methyl-2-(phenylthio)-6-p-tolylpyrimidine-5-carboxylate 

Relevant academic research and scientific papers

Supramolecular synthesis of 3,4-dihydropyrimidine-2(1H)-one/thiones under neat conditions

An efficient solvent free method for the synthesis of various 3,4-dihydropyrimidin-2(1H)-one/thiones in excellent yields using sulfonated β-cyclodextrine as recyclable catalyst is described. Sulfonated β-cyclodextrine was found to be efficient, recyclable

Boron trioxide-alumina as a heterogeneous catalyst in a facile solvent free one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones

B2O3/Al2O3 has been found to be a new and highly efficient heterogeneous catalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones by the Biginelli reaction under solvent-free conditions. 3,4-Dihydropyrimidin-2(1H)-ones have important pharmacological and biological activities.

Microwave-assisted synthesis of dihydropyrimidin-2(1H)-ones using graphite supported lanthanum chloride as a mild and efficient catalyst

Graphite supported lanthanum chloride efficiently catalyzes the three-component coupling of β-ketoesters, aldehydes and urea/thiourea to afford corresponding dihydropyrimidinones in good yields under microwave irradiation.

Poly(N-vinyl-2-pyrrolidone)-supported ferric chloride: An effective reusable heterogeneous catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via three-component Biginelli reaction

An environmentally benign three-component Biginelli protocol for the one-pot synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones/thiones using an accessible, nontoxic, easy to handle, and recoverable macromolecular Lewis acidic catalyst is developed.

Amino acid ionic liquid-catalyzed synthesis, anti-Leishmania activity, molecular docking, molecular dynamic simulation, and ADME study of 3,4-dihydropyrimidin-2(1H)-(thio)ones

The synthesis of 3,4-dihydropyrimidin-2(1H)-(thio)one (DHPM) derivatives involving aromatic aldehyde, β-ketoesters and urea/thiourea using prolinium hydrogen sulfate (ProHSO4) as a catalyst has been studied. A variety of DHPM derivatives were o

Green synthesis, structural analysis and anticancer activity of dihydropyrimidinone derivatives

In this study, for the first time, we have used Citrus macroptera juice to synthesize dihydropyrimidine (DHPM) derivatives via the Biginelli reaction, which showed better yield, shorter reaction time, and did not require an organic solvent for the reactio

Aiding the versatility of simple ammonium ionic liquids by the synthesis of bioactive 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives

Simple ammonium ionic liquids [ILs] are efficient, green, environmentally friendly catalysts in promoting the Biginelli condensation reaction, Hantzsch reaction and Niementowski reaction to afford 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives respectively by eliminating the need for harmful volatile organic solvents. These [ILs] are air and water stable, easy to prepare and cost-effective. The effects of the anions and cations present in [IL] on reactions were investigated. The results clearly indicated that the Biginelli condensation reaction, Hantzsch reaction and Niementowski reaction were heavily influenced by the acidity of [IL], and among various ammonium ionic liquids, [Et3NH][HSO4] showed the best catalytic activity. Furthermore, [IL] could be easily separated and reused with a slight loss of its activity. This technique provided a good alternative way for the industrial synthesis of 1,2,3,4-tetrahydropyrimidinones, 2-aminothiazoles and quinazolinones. The present processes are eco-friendly methods for the synthesis of these derivatives authenticated by several green parameters, namely,E-factor, process mass intensity, reaction mass efficiency, atom economy, and carbon efficiency.

Synthesis method of dihydropyrimidinone compound

The invention discloses a synthesis method of a dihydropyrimidone compound, which belongs to the technical field of organic synthesis, and comprises the following steps: by taking benzaldehyde or a derivative thereof, ethyl acetoacetate or acetylacetone a

Efficient one-pot synthetic methods for the preparation of 3,4-dihydropyrimidinones and 1,4-dihydropyridine derivatives using BNPs?SiO2(CH2)3NHSO3H as a ligand and metal free acidic heterogeneous nano-catalyst

Heterocyclic compounds with biological and pharmacological activates like 3,4-dihydropyrimidin-2-(1H)-ones and 1,4-dihydropyridines have attracted great interest. Boehmite nanoparticles functionalized with silylpropyl sulfamic acid (BNPs?SiO2(C

Natural dolomitic limestone-catalyzed synthesis of benzimidazoles, dihydropyrimidinones, and highly substituted pyridines under ultrasound irradiation

Natural dolomitic limestone (NDL) is employed as a heterogeneous green catalyst for the synthesis of medicinally valuable benzimidazoles, dihydropyrimidinones, and highly functionalized pyridines via C–N, C–C, and C–S bond formations in a mixture of ethan