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1-(1,3-benzodioxol-5-yl)-3-chloropropan-1-one, commonly known as safrole, is a chemical compound with the molecular formula C10H9ClO3. It is a colorless or slightly yellow oily liquid that can be extracted from sassafras oil and certain other essential oils. Safrole is widely recognized for its use in the synthesis of pharmaceuticals, fragrances, and flavors. However, it has also been identified as a precursor in the illicit production of MDMA (ecstasy), leading to regulated use and distribution in many countries. Despite its potential risks, safrole has been classified as a potential carcinogen by the International Agency for Research on Cancer. Nevertheless, it has demonstrated certain medicinal properties, suggesting possible future therapeutic applications.

84707-83-5

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84707-83-5 Usage

Uses

Used in Pharmaceutical Synthesis:
1-(1,3-benzodioxol-5-yl)-3-chloropropan-1-one is used as a key intermediate in the synthesis of various pharmaceuticals due to its unique chemical structure and reactivity. Its ability to form a range of derivatives makes it a valuable compound in the development of new medications.
Used in Fragrance and Flavor Industries:
Safrole is utilized as a building block for creating different fragrances and flavors in the perfumery and flavor industries. Its distinct aromatic properties contribute to the development of unique scents and tastes in various consumer products.
Used in Illicit Drug Manufacture:
Although regulated, 1-(1,3-benzodioxol-5-yl)-3-chloropropan-1-one has been identified as a precursor in the production of the illicit drug MDMA (ecstasy). Its use in this context highlights the dual nature of the compound, which can be both beneficial and harmful depending on the application.
Potential Therapeutic Applications:
Despite its classification as a potential carcinogen, safrole has shown certain medicinal properties. It may have future therapeutic applications once its risks are better understood and managed, possibly contributing to the development of new treatments for various health conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 84707-83-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,7,0 and 7 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 84707-83:
(7*8)+(6*4)+(5*7)+(4*0)+(3*7)+(2*8)+(1*3)=155
155 % 10 = 5
So 84707-83-5 is a valid CAS Registry Number.

84707-83-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(1,3-benzodioxol-5-yl)-3-chloropropan-1-one

1.2 Other means of identification

Product number -
Other names 3-chloro-1-(1,2-methylenedioxybenzen-4-yl)-propanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:84707-83-5 SDS

84707-83-5Relevant academic research and scientific papers

First total synthesis of piperodione and analogs

Sommerwerk, Sven,Kern, Simone,Heller, Lucie,Csuk, René

supporting information, p. 6243 - 6244 (2015/02/19)

Piperodione (3), a secondary metabolite previously isolated from the Javanese pepper plant Piper retrofractum in 0.0002% isolated yield was synthesized in a convergent strategy utilizing a Mannich and a Stetter reaction. An over-all yield of 76% could be achieved. Several analogs were prepared by this synthetic sequence. None of the compounds showed a significant cytotoxicity for human tumor cells (photometric sulforhodamine B assay).

ARALKYL DIAMINE DERIVATIVES AND USES THEREOF AS ANTIDEPRESSANTS

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Paragraph 0158, (2013/03/28)

Aralkyl diamine derivative of the following formula, pharmaceutically acceptable salts or uses thereof as antidepressants. The derivatives have triplex inhibiting activities of the reuptake of 5-HT, dopamine and noradrenalin, which can be administered to the patients in need of such treatment in the form of compositions orally or injectedly et al.

ARALKYL DIAMINE DERIVATIVES AND USES THEREOF AS ANTIDEPRESSANT

-

Paragraph 0026; 0144, (2013/03/28)

Aralkyl diamine derivative of the following formula, pharmaceutically acceptable salts or uses thereof as antidepressants. The derivatives have triplex inhibiting activities of the reuptake of 5-HT, dopamine and noradrenalin, which can be administered to the patients in need of such treatment in the form of compositions orally or injectedly et al.

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