847159-09-5Relevant academic research and scientific papers
Process development and large-scale synthesis of NK1 antagonist
Araya, Ichiro,Kanazawa, Shintaro,Akita, Hiroyuki
, p. 176 - 180 (2008)
A scaleable synthetic route is described to obtain 2-(4-acetylpiperadin-1- yl)-6-[3,5-bis(trifluoromethyl)-phenylmethyl]-4-(2-methylphenyl)-6,7,8, 9-tetrahydro-5H-pyrimido[4,5-b][1,5]oxazocin-5-one (1, KRP-103) as a neurokinin (NK)1 antagonist.
