847248-61-7

Upstream product

• 66-77-3 1-naphthaldehyde 
• 847248-59-3 3-bromo-5-(hydroxynaphthalen-1-ylmethyl)-4-methoxy-5H-furan-2-one 
• 873431-42-6 5-(hydroxy-naphthalen-1-yl-methyl)-4-methoxy-5H-furan-2-one 
• 847248-60-6 3-bromo-4-methoxy-5[(Z)-1-naphthylmethylidene]furan-2(5H)-one 
• 1679-18-1 4-Chlorophenylboronic acid 

Relevant academic research and scientific papers

Pulvinones as bacterial cell wall biosynthesis inhibitors

Pulvinones were synthesized (>180) in arrays and evaluated as inhibitors of early stage cell wall biosynthesis enzymes MurA-MurD. Several pulvinones inhibited Mur enzymes with IC50's in the 1-10 μg/mL range and demonstrated antibacterial activity against Gram-positive bacteria including methicillin-resistant Staphyloccus aureus, vancomycin-resistant Enterococcus faecalis, and penicillin-resistant Streptococcus pneumoniae.

3-Aryl-4-Hydroxyfuranone compounds and the human and animal health use thereof

The present invention provides a compound of formula I and the use thereof for the inhibition of bacterial cell wall biosynthesis and for the therapeutic treatment of bacterial infection or disease in a patient in need thereof. The present invention also