84726-81-8

Basic information

• Product Name: 2-(2-HYDROXYETHYLAMINO)-N-PHENYLACETAMIDE
• Synonyms: 2-(2-HYDROXYETHYLAMINO)-N-PHENYLACETAMIDE
• CAS NO: 84726-81-8
• Molecular Formula: C₁₀H₁₄N₂O₂
• Molecular Weight: 194.23036
• Mol File: 84726-81-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 450.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.200±0.06 g/cm3(Predicted)
• PKA: 14.21±0.70(Predicted)
• CAS DataBase Reference: 2-(2-HYDROXYETHYLAMINO)-N-PHENYLACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-HYDROXYETHYLAMINO)-N-PHENYLACETAMIDE(84726-81-8)
• EPA Substance Registry System: 2-(2-HYDROXYETHYLAMINO)-N-PHENYLACETAMIDE(84726-81-8)

Safety Data

• Hazardous Substances Data: 84726-81-8(Hazardous Substances Data)

Usage

General Description

2-(2-Hydroxyethylamino)-N-phenylacetamide, also known as Rofecoxib, is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain and inflammation in conditions such as arthritis. It works by inhibiting the production of prostaglandins, which are involved in pain and inflammation. Rofecoxib was once widely used for its pain-relieving properties, but it was withdrawn from the market due to concerns about its cardiovascular side effects. Despite its withdrawal, it is still used in some countries for limited indications and research purposes.

Upstream product

• 62-53-3 aniline 
• 141-43-5 ethanolamine 
• 79-04-9 chloroacetyl chloride 
• 587-65-5 N-chloroacetyl-aniline 

Downstream Products

• 90917-86-5 1-phenyl-2-piperazinone 
• 94783-18-3 1-phenyl-2-piperazinone hydrochloride 

Relevant articles and documents

Sequence-Defined Dithiocarbamate Oligomers via a Scalable, Support-free, Iterative Strategy

Precise control over the monomeric sequence on natural sequence-defined polymers (SDPs) leads to their structural diversity and functions. However, absolute control over the monomeric sequence on a synthetic polymer remains a challenging process. Herein, we describe a support-free, protection-deprotection-free, cost-effective, and fast iterative strategy for multigram production of a new class of SDP with a unique functional group, dithiocarbamate, a potential group for material and biomedical applications. The strategy is based on a unique monomer, named as amine-hydroxyl monomer, and a three-component reaction between the monomer, CS2, and terminal chloro group of the growing chain. The fast strategy allows us to synthesize a 5-mer sequence-defined oligomer in 6 h. For a proof of concept, a range of aliphatic and aromatic groups have been incorporated at different sequences in the sequence-defined oligomer. This SDP platform has further been advanced by two ways: (i) multiple approaches for postsynthetic modification of SDP and (ii) increasing the chain length in a single step.

Efficient synthesis of N-arylpiperazinones via a selective intramolecular Mitsunobu cyclodehydration

A practical two pot synthesis of N-arylpiperazinones from the corresponding aniline is described. The key transformation is a selective intramolecular Mitsunobu cyclodehydration of an amidoalcohol intermediate. A series of N-arylpiperazinones were prepared in yields up to 89%.