84733-04-0

Upstream product

• 1027627-26-4 C₂₀H₃₄OSi₂ 
• 104-53-0 3-phenyl-propionaldehyde 
• 99902-35-9 5-phenylpent-1-yn-3-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 140149-77-5 5-phenyl-1-trimethylsilylpent-1-yn-3-ol 
• 69739-34-0 t-butyldimethylsiyl triflate 

Downstream Products

• 155624-50-3 7-Phenyl-5-(tert-butyldimethylsiloxy)-1,1,1-trifluoro-3-heptyn-2-one 
• 184577-40-0 (+/-)-1-phenylhex-4-yn-3-ol 
• 122124-41-8 1-phenylhex-4-yn-3-one 
• 1308659-41-7 7-(tert-butyldimethylsilyloxy)-6-methylene-9-phenylnon-4-ene-1-ol 
• 155624-52-5 trans-7-Phenyl-5-(tert-butyldimethylsiloxy)-1,1,1-trifluoro-3-hepten-2-one 
• 155624-38-7 4-Thiophenoxy-2-hydroxy-2-(trifluoromethyl)-5-phenethyltetrahydrofuran 
• 155624-53-6 trans-7-Phenyl-5-hydroxy-1,1,1-trifluoro-3-hepten-2-one 
• 143140-88-9 (tert-butyl)(dimethyl)(2-methylidene-1-phenethyl-but-3-enyloxy)silane 
• 845508-88-5 Z-(tert-butyl)(dimethyl)(2-methylidene-1-phenethyl-oct-3-enyloxy)silane 

Relevant academic research and scientific papers

C-F bond cleavage enabled redox-neutral [4+1] annulation via C-H bond activation

Using α,α-difluoromethylene alkyne as a nontraditional one-carbon reaction partner, a synthetically novel method for the construction of isoindolin-1-one derivatives via Rh(III)-catalyzed [4+1] annulation reaction is reported. The 2-fold C-F bond cleavage not only enables the generation of desired product under an overall oxidant-free condition but also results in a net migration of carbon-carbon triple bond. In addition, the present reaction protocol exhibits a tolerance of a wide spectrum of functional groups due to the mild reaction conditions employed.

One-Pot, Three-Step Synthesis of Cyclopropylboronic Acid Pinacol Esters from Synthetically Tractable Propargylic Silyl Ethers

Simple propargylic silyl ethers can be converted to complex cyclopropylboronic acid pinacol esters in an efficient one-pot procedure. Terminal acetylenes undergo a Schwartz's reagent catalyzed hydroboration; subsequent addition of further Schwartz's reage

DBU-promoted facile, chemoselective cleavage of acetylenic TMS group

Acetylenic trimethylsilyl (TMS) groups were efficiently removed using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). With either 1.0 or even 0.1 equivalents of DBU, smooth desilylation of various terminal acetylenic TMS groups was accomplished selectively in the presence of alkyl silyl ethers and other base-labile groups. Furthermore, more sterically hindered terminal acetylenic silyl groups such as TBDMS and TIPS remained intact under these conditions. Georg Thieme Verlag Stuttgart.

Synthesis of and Analysis of Thiol Additions to β-Alkyl-α,β-unsaturated Trifluoromethyl Ketones

A series of β-alkyl-α,β-unsaturated trifluoromethyl ketones have been prepared from the corresponding α-acetylenic trifluoromethyl ketones.The addition of sulfur nucleophiles was shown by chemical and 19F NMR studies to proceed exclusively by 1,4-addition with no indication of any 1,2-addition products.The unsaturated trifluoromethyl ketones have been shown to be effective inhibitors of rat cytosolic glutathione-S-transferase.

Novel substituted (4.2.0)bicyclooctane derivatives with valuable therapeutic properties

Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension and atherosclerosis are depicted in formulas (1), (2) and (3): STR1 wherein: A is --C C--, trans --HC=CH--, --CH2 CH2 -- or --CH=CHCH2 --; X is lower alkoxy, hydroxy, or (2,2,2)-trifluoroethoxy; Y is hydrogen, exo-(lower alkyl) or endo-(lower alkyl); is an integer of 2-4; R1 is --CH2 OH, --CHO, --CO2 R or --CO2 H, and the olefin formed by the R1 (CH2)n CH= moiety is either (E) or (Z); R2 is hydrogen or methyl, or optionally --CH=CH2 when A is --CH=CHCH2 --; and R3 is linear or branched alkyl, alkenyl or alkynyl having 5-10 carbon atoms, STR2 --(CH2)m -phenyl or CH2 O-phenyl; in which each phenyl may be optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen; in which: a is an integer of 0, 1 or 2; b is an integer of 3-7; m is an integer of 0, 1 or 2; and R is STR3 wherein x is STR4 in which each R4 is independently hydrogen or lower alkyl having 1-6 carbon atoms, and the pharmaceutically acceptable, non-toxic salts and esters thereof.

Novel 8-(lower alkyl)bicyclo[4.2.0]octane derivatives with valuable therapeutic properties

Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension, and atherosclerosis are compounds depicted in formulas (1), (2), and (3): STR1 wherein: Y is exo-(lower alkyl) or endo-(lower alkyl); n is 2 or 3; R1 is CH2 OH, CHO, CO2 R or CO2 H; R2 is hydrogen or methyl; and R3 is linear or branched alkyl having 5-10 carbon atoms, STR2 or --(CH2)m -phenyl optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen, in which a is 0, 1 or 2; b is 3-7; m is 1 or 2; and R is STR3 wherein X is STR4 in which each R4 is independently hydrogen or lower alkyl having 1-6 carbon atoms, and the pharmaceutically acceptable, non-toxic salts and esters thereof.

Novel [4,2,0]bicyclooctane derivatives with valuable therapeutic properties

Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension, and atherosclerosis are compounds depicted in formulas (1), (2), and (3): STR1 wherein: n is 2 or 3; R1 is CH2 OH, CHO, CO2 R or CO2 H; R2 is hydrogen or methyl; and R3 is linear or branched alkyl having 5-10 carbon atoms, STR2 optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen, in which a is 0, 1 or 2; b is 3-7; m is 1 or 2; and R is STR3 in which each R4 is independently hydrogen or lower alkyl having 1-6 carbon atoms, and the pharmaceutically acceptable, non-toxic salts and esters thereof.