155624-50-3Relevant academic research and scientific papers
Synthesis of and Analysis of Thiol Additions to β-Alkyl-α,β-unsaturated Trifluoromethyl Ketones
Linderman, Russell J.,Jamois, Eric A.,Tennyson, Scott D.
, p. 957 - 962 (1994)
A series of β-alkyl-α,β-unsaturated trifluoromethyl ketones have been prepared from the corresponding α-acetylenic trifluoromethyl ketones.The addition of sulfur nucleophiles was shown by chemical and 19F NMR studies to proceed exclusively by 1,4-addition with no indication of any 1,2-addition products.The unsaturated trifluoromethyl ketones have been shown to be effective inhibitors of rat cytosolic glutathione-S-transferase.
