84737-23-5

Usage

Uses

Used in Agrochemical Industry:
2,4,5-trichloro-4-trifluoropyriMidine is used as an intermediate in the production of agrochemicals for its herbicidal properties. It contributes to the formulation of weed control products, helping to manage and eliminate unwanted plant growth in agricultural settings.
Used in Pharmaceutical Industry:
2,4,5-trichloro-4-trifluoropyriMidine is also utilized in the synthesis of pharmaceuticals, where its chemical structure can be further modified to create new drugs with potential therapeutic applications.
Used in Organic Synthesis:
2,4,5-trichloro-4-trifluoropyriMidine is employed in the synthesis of other organic compounds, broadening its applications across various chemical industries that rely on the creation of novel organic molecules for different purposes.
Safety Precautions:
It is crucial to handle 2,4,5-trichloro-4-trifluoropyriMidine with care due to its potential to cause irritation to the skin, eyes, and respiratory system upon exposure. Adhering to proper safety procedures is essential to minimize health risks associated with this chemical compound.

InChI:InChI=1/C5Cl3F3N2/c6-1-2(5(9,10)11)12-4(8)13-3(1)7

Upstream product

• 85730-40-1 5-Chloro-6-trifluoromethyluracil 
• 121-69-7 N,N-dimethyl-aniline 

Downstream Products

• 93669-60-4 5-Chloro-2-methoxy-4-N-methylanilino-6-trifluoromethylpyrimidine 
• 93669-63-7 4-N-Methylanilino-6-trifluoromethylpyrimidin-2-ol 
• 93669-55-7 5-Chloro-2,4-bis(N-methylanilino)-6-trifluoromethylpyrimidine 
• 93669-59-1 2,5-Dichloro-4-N-methylanilino-6-trifluoromethylpyrimidine 

Relevant academic research and scientific papers

Pyrimidines. 7. A Study of the Chlorination of Pyrimidines with Phosphorus Oxychloride in the Presence of N,N-Dimethylaniline

The chlorination of 6-trifluoromethyluracils by phosphorus oxychloride in the presence of N,N-dimethylaniline was studied and compared with results obtained with 6-methyluracils. 6-Trifluoromethyluracils and its 5-chloro analog afforded moderate yields of the di- and trichloropyrimidines, accompanied by good yields of the 2-N-methylanilino by-products, after a 3-hour reaction time.After 24 hours, the 2-N-methylanilinopyrimidines were the primary or sole products.A small yield of 2,4-bis(N-methylanilino)-6-trifluoromethylpyrimidine was also obtained.The 6-methyluracils afforded high yields of the di- and trichloropyrimidines, after 3 and 24 hours, along with minor amounts of the 2-N-methylanilino by-products.After 48 hours, the proportion of 2,4-dichloro-6-methylpyrimidine decreased, and the 2-N-methylanilino product increased. 2-Chloro-4-methylanilino-6-methylpyrimidine and bis(2-N-methylanilino)-6-methylpyrimidine were also formed in small amounts.The chlorination products from 5-chloro-6-methyluracil remained constant over 188 hours of reaction time. It appears that the Π electron distribution around the ring, as influenced by the substituents, controls the course of the chlorination and by-product formation.Since the amination by a tertiary amine is a type of Hoffmann reaction, the presence of the chlorine in 5 position of the ring adds steric hindrance and thus enhances the regiospecificity of the formation of by-products.