847375-92-2Relevant academic research and scientific papers
Selective disaccharide binding by a macrotetracyclic receptor
Klein, Emmanuel,Ferrand, Yann,Auty, Elizabeth K.,Davis, Anthony P.
, p. 2390 - 2392 (2007)
A new carbohydrate receptor possesses a C3-symmetric polar cavity capable of encapsulating disaccharides; binding to β-maltosyl is preferred, complementing previous systems which have favoured "all-equatorial" substrates. The Royal Society of C
New H-bonding patterns in biphenyl-based synthetic lectins; Pyrrolediamine bridges enhance glucose-selectivity
Joshi, Gururaj,Davis, Anthony P.
supporting information; experimental part, p. 5760 - 5763 (2012/08/28)
Synthetic lectins are molecules designed for the challenging task of biomimetic carbohydrate recognition in water. Previous work has explored a family of such systems based on bi/terphenyl units as hydrophobic surfaces and isophthalamide spacers to provide polar binding groups. Here we report a related receptor which employs a new spacer, 2,5-bis-(aminomethyl)-pyrrole, with an alternative (A-D-A) set of H-bonding valencies. The modified spacer leads to significant changes in binding selectivity, including a preference for glucose over all other tested substrates.
Carbohydrate recognition in water by a tricyclic polyamide receptor
Klein, Emmanuel,Crump, Matthew P.,Davis, Anthony P.
, p. 298 - 302 (2007/10/03)
A sweet center: Most carbohydrates are supremely comfortable in water. Can they be tempted to leave? Yes, if their new home satisfies all their needs. The watersoluble receptor 1 (R = polycarboxylate) provides hydrophobic surfaces (purple) for CH groups a
