847448-40-2

Upstream product

• 64-18-6 formic acid 
• 847448-37-7 [(S)-1-(3,4-Difluoro-phenyl)-propylamino]-acetic acid methyl ester 
• 847448-46-8 (S)-1-(3,4-Difluoro-phenyl)-propylamine 

Relevant academic research and scientific papers

2-Mercaptoimidazoles, a new class of potent CCR2 antagonists

We describe the synthesis and SAR of a new class of CCR2 antagonists based on a 2-mercaptoimidazole scaffold. The initial lead 1a was optimized to the 3,4-disubstituted analogues 1p-(S) and 1q-(S), which have IC50 values in the MCP-1 induced Ca

MERCAPTOIMIDAZOLES AS CCR2 RECEPTOR ANTAGONISTS

The present invention relates to a compound of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine, a polymorphic form or a stereochemically isomeric form thereof, wherein R1 represents hydrogen, C1-6alkyl, C3-7cycloalky