847469-01-6

Upstream product

• 100-39-0 benzyl bromide 
• 205380-30-9 (R)-2-(2-hydroxy-1-phenylethyl)-1H-isoindole-1,3(2H)-dione 
• 85-44-9 phthalic anhydride 
• 56613-80-0 D-2-phenylglycinol 

Downstream Products

• 847469-02-7 2-((R)-2-Benzyloxy-1-phenyl-ethyl)-3-hydroxy-3-methyl-2,3-dihydro-isoindol-1-one 

Relevant academic research and scientific papers

PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS

Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Studies on the diastereoselective reductive alkylation of (R)-phenylglycinol derived phthalimide: Observation of stereoelectronic effects

Full details of a flexible approach to N-protected (R)-3-alkyl-isoindolin- 1-ones 13 via diastereoselective reductive-alkylation are described, with emphasis on the stereochemical outcome of the key diastereoselective reactions. Additional experiments allowed finding remarkable stereoelectronic effects on the reductive ring-opening reactions.