84755-40-8

Upstream product

• 84755-39-5 acide (benzyloxy-4 methoxy-3 phenyl)-4 methoxycarbonyl-3 butene-3 oique 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 92831-74-8 4-<<4-(benzyloxy)-3-methoxyphenyl>methyl>dihydro-2(3H)-furanone 
• 111194-04-8 3-methoxycarbonyl-4-(4-hydroxy-3-methoxyphenyl)butanoic acid 
• 92831-72-6 (benzyloxy-4 methoxy-3 benzylidene)-4 dihydro-3H-furannone-2 

Downstream Products

• 127951-04-6 (+/-)-2-(4-Benzyloxy-3-methoxybenzyl)-3-(α-benzyloxy-4-hydroxy-3-methoxybenzyl)butan-4-olide 
• 5447-65-4 O-diacetyl-(+/-)-α-conidendrine 
• 127951-05-7 (+/-)-2-(4-Hydroxy-3-methoxybenzyl)-3-(α-benzyloxy-4-hydroxy-3-methoxybenzyl)butan-4-olide 
• 518-55-8 (+/-)-α-Conidendrine 
• 140193-25-5 (+/-)-3-<α-Benzyloxy-4-(tertio-butyl dimethylsiloxy)-3-methoxybenzyl>butan-4-olide 
• 140193-24-4 (+/-)-3-<α-Bromo-4-(tertio-butyl dimethylsiloxy)-3-methoxybenzyl>butan-4-olide 
• 92831-77-1 benzyloxy-7 methoxy-6 (benzyloxy-4 dimethoxy-3,5 phenyl)-9 tetrahydro-3a,4,9,9a naphto<2,3-c>furannone-1 (3H) 
• 92831-80-6 (benzyloxy-4 dimethoxy-3,5 phenyl)-1-r bis-hydroxymethyl-2-t, 3-c benzyloxy-7 methoxy-6 tetrahydro-1,2,3,4 naphtalene 
• 92831-75-9 <(benzyloxy-4 dimethoxy-3,5 phenyl) hydroxymethyl>-3 (benzyloxy-4 methoxy-3 benzyl)-4 dihydro-3H-furannone-2 
• 92831-78-2 <(dimethoxy-3,5 hydroxy-4 phenyl) hydroxymethyl>-3 (benzyloxy-4 methoxy-3 benzyl)-4 dihydro-3H-furannone-2 
• 92831-79-3 benzyloxy-7 methoxy-6 (dimethoxy-3,5 hydroxy-4 phenyl)-9 tetrahydro-3a,4,9,9a naphto<2,3-c>furannone-1 (3H) 
• 92831-81-7 (dimethoxy-3,5 hydroxy-4 phenyl)-1-r bis-hydroxymethyl-2-t, 3-c hydroxy-7 methoxy-6 tetrahydro-1,2,3,4 naphtalene 
• 92831-76-0 hydroxy-7 methoxy-6 (dimethoxy-3,5 hydroxy-4 phenyl)-9 tetrahydro-3a,4,9,9a naphto<2,3-c>furannone-1 (3H) 
• 127951-04-6 4-[Benzyloxy-(4-hydroxy-3-methoxy-phenyl)-methyl]-3-(4-benzyloxy-3-methoxy-benzyl)-dihydro-furan-2-one 

Relevant academic research and scientific papers

Biosynthesis of yatein in Anthriscus sylvestris.

Little is known about the biosynthesis of yatein, in spite of its importance as a typical heartwood lignan and a key biosynthetic intermediate of the antitumor lignan podophyllotoxin. The present study, based on individual administration of [13C]phenylalanine and deuterium labelled lignans and simultaneous administration of two distinct lignans labelled with deuterium atoms to Anthriscus sylvestris, established the two independent branch pathways from matairesinol, one to afford yatein via thujaplicatin, 5-methylthujaplicatin, and 4,5-dimethylthujaplicatin and the other to bursehernin via pluviatolide. The latter pathway did not lead to yatein, eliminating the presence of a metabolic grid from matairesinol to yatein.

FIRST TOTAL SYNTHESIS OF (-)-α-CONIDENDRIN

Regioselective introduction of a benzoxy group, in the benzylic position of the β-benzyl-γ-butyrolactone (R)-(+)-8, was achieved by treatment with NBS followed with benzyl alcohol. α-Alkylation of the lithium enolate of the resulting intermediate 11, with