84756-61-6Relevant academic research and scientific papers
Testosterone prodrugs for improved drug delivery
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, (2008/06/13)
Compositions and methods are provided for enhanced transdermal electrotransport of 17-hydroxy sterol compounds, including testosterone. The parent sterols are modified at the 17-hydroxy position by covalent attachment of a charged chemical modifier. The chemical modifier provides the parent sterol with enhanced transport properties and is hydrolyzed under physiological conditions to release the active parent compound. The composition comprises a 17-hydroxy sterol/chemical modifier complex, more generally represented by the formula (sterol--O--)C(O)--R--N(R1)(R2)(R3)+. The portion of the complex derived from the chemical modifier is indicated by "C(O)--R--N(R1)(R2)(R3)+ ", where N(R1)(R2)(R3)+ represents a quaternary ammonium group and R1, R2, and R3 are independently selected from the group consisting of lower alkyl, alkyl, aryl, arylalkyl, cycloalkyl, heteroalkyl, and heteroarylalkyl; or R1 and R2 together with the nitrogen to which they are attached form a substituted heterocycle and R3 is lower alkyl, and R is a linking moiety, linking the (sterol--O)--C(O)-- to the nitrogen atom.
Compositions and methods for enhanced drug delivery
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, (2008/06/13)
The present invention relates to methods of delivering pharmaceutical agents across membranes, including the skin layer or mucosal membranes of a patient. A pharmaceutical agent is covalently bonded to a chemical modifier, via a physiologically cleavable bond, such that the membrane transport and delivery of the agent is enhanced.
Bis-hydroxymethyl carbonate bridged antibacterial agents
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, (2016/03/01)
Antibacterial agents in which a penicillin and a beta-lactamase inhibitor are linked by means of a bis-hydroxymethyl carbonate bridge are of the formula: STR1 and pharmaceutically acceptable acid addition salts thereof, wherein R1 is hydrogen, hydroxy, certain acyloxy or certain alkoxycarbonyloxy groups, a method for their use, pharmaceutical compositions thereof, and intermediates useful in their production.
