50594-94-0Relevant academic research and scientific papers
Compositions and methods for enhanced drug delivery
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, (2008/06/13)
The present invention relates to methods of delivering pharmaceutical agents across membranes, including the skin layer or mucosal membranes of a patient. A pharmaceutical agent is covalently bonded to a chemical modifier, via a physiologically cleavable bond, such that the membrane transport and delivery of the agent is enhanced.
Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons
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, (2008/06/13)
Contrast agents comprising gas-containing or gas-generating polymer microparticles and/or microballoons, in which the polymer is a biodegradable polymer containing units of formula (wherein R1 and R2 each represent hydrogen or a carbon-attached monovalent organic group or together form a carbon-attached divalent organic group, and m and n are each independently zero or one) may be used in diagnostic applications such as ultrasound and MR imaging.
Cleavage of carbon-sulfur bonds in the synthesis of α-haloalkyl carbonates
Hatlelid, Jostein,Benneche, Tore,Undheim, Kjell
, p. 1041 - 1044 (2007/10/03)
α-Chloroalkyl and α-bromoalkyl carbonates have been prepared by cleavage of α-arylthioalkyl carbonates with sulfuryl chloride or bromine, respectively. The α-arylthioalkyl carbonates are prepared by reaction of the hemithioacetal 1 with chloroformates or by a destannylative tin-Pummerer rearrangement of α-stannyl sulfoxides. Acta Chemica Scandinavica 1996.
