847584-68-3

Upstream product

• 847585-55-1 6-(4-phenylbutoxy)-3,4-dihydronaphthalen-1(2H)-one 
• 1314760-19-4 C₂₁H₂₆O₂ 
• 872710-28-6 4-methyl-7-(4-phenylbutoxy)-1,2-dihydronaphthalene 
• 1314760-20-7 C₂₂H₂₄O₂ 
• 847586-14-5 C₂₅H₃₁NO₃ 
• 13633-25-5 1-Bromo-4-phenylbutane 
• 3470-50-6 6-Hydroxy-1-tetralone 

Relevant academic research and scientific papers

Discovery of S1P agonists with a dihydronaphthalene scaffold

Structure-activity relationship of sphingosine-1-phosphate receptor agonists was examined. Cinnamyl derivative 1 was modified to improve S1P 1 agonistic activity as well as selectivity over S1P3 agonistic activity. Dihydronaphthalene derivative 10d was identified as a potent S1P1 receptor agonist with high selectivity against S1P3 and enhanced efficacy in lowering peripheral lymphocyte counts in mice.