847585-55-1

Upstream product

• 13633-25-5 1-Bromo-4-phenylbutane 
• 3470-50-6 6-Hydroxy-1-tetralone 

Downstream Products

• 847584-69-4 1-{[1-methyl-6-(4-phenylbutoxy)-3,4-dihydro-2-naphthalenyl]methyl}-3-azetidinecarboxylic acid hydrochloride 
• 847586-08-7 1-{[1-methyl-6-(4-phenylbutoxy)-3,4-dihydronaphthalen-2-yl]methyl}azetidine-3-carboxylic acid 
• 847584-68-3 3-({[1-methyl-6-(4-phenylbutoxy)-3,4-dihydro-2-naphthalenyl]methyl}amino)propanoic acid hydrochloride 
• 847586-14-5 C₂₅H₃₁NO₃ 
• 1314760-20-7 C₂₂H₂₄O₂ 
• 872710-28-6 4-methyl-7-(4-phenylbutoxy)-1,2-dihydronaphthalene 
• 847584-79-6 3-({[6-(4-phenylbutoxy)-3,4-dihydro-2-naphthalenyl]methyl}amino)propanoic acid hydrochloride 
• 847736-52-1 C₂₄H₂₉NO₃ 
• 1314760-16-1 C₂₁H₂₂O₂ 
• 1314760-11-6 C₂₀H₂₄O₂ 

Relevant academic research and scientific papers

Discovery of S1P agonists with a dihydronaphthalene scaffold

Structure-activity relationship of sphingosine-1-phosphate receptor agonists was examined. Cinnamyl derivative 1 was modified to improve S1P 1 agonistic activity as well as selectivity over S1P3 agonistic activity. Dihydronaphthalene derivative 10d was identified as a potent S1P1 receptor agonist with high selectivity against S1P3 and enhanced efficacy in lowering peripheral lymphocyte counts in mice.