847654-05-1Relevant academic research and scientific papers
Bis-glycinato complexes of palladium(II): Synthesis, structural determination, and hydrogen bonding interactions
Hobart Jr., David B.,Berg, Michael A.G.,Merola, Joseph S.
, p. 21 - 30 (2014/12/09)
Palladium(II) acetate and palladium(II) chloride react with glycine and glycine derivatives in acetone/water to yield square planar bis-chelated palladium amino acid complexes. Glycine, N-methylglycine and N,N-dimethylglycine all adopt the trans configuration when prepared from palladium(II) acetate, whereas glycine adopts a cis configuration when prepared from palladium(II) chloride. The crystal structures of all four complexes were obtained. The extended lattice structures arise from N-H··O or O··(HOH)··O hydrogen bonding. Nuclear magnetic resonance, infrared, high resolution mass spectroscopy, and UV-Vis spectroscopic data are evaluated.
TRANSITION METAL COMPLEXES OF AMINO ACIDS AND RELATED LIGANDS AND THEIR USE AS CATALYSTS, ANTI-MICROBIALS, AND ANTI-CANCER AGENTS
-
Paragraph 0260, (2013/04/24)
The present invention relates to the fields of chemistry and pharmaceuticals. Embodiments of the present invention provide transition metal complexes of amino acids. Transition metal complexes of embodiments of the invention according to Categories I, II, III, and/or IV may be used as antimicrobial, anti-malarial, and anti-cancer agents, as well as catalysts in chemical reactions. Such compounds of the invention are particularly useful for combating multi-drug resistance against a broad range of microbials (such as MRSA and mycobacteria), including gram positive and gram negative bacteria, as well as can be used as anti-cancer agents against bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, leukemia, lung cancer, melanoma, non-Hodgkin's lymphoma, pancreatic cancer, prostate cancer, and thyroid cancer, to name a few.
Mapping the mechanism of nickel-ferrophite catalysed methylation of baylis-hillman-derived SN2′ electrophiles
Novak, Andrew,Calhorda, Maria Jose,Costa, Paulo Jorge,Woodward, Simon
experimental part, p. 898 - 903 (2009/07/19)
Enantioselective Ni-catalysed methylation of Baylis-Hillman-derived allylic electrophiles in the presence of ferrophite ligands has been investigated computationally and experimentally. The sense and degree of enantioselectivity attained is independent of both the leaving group and the isomeric structure of the initial allylic halide. DFT studies support the selective formation of a limited number of energetically favoured anti and syn π-allyl intermediates. The observed regio- and enantioselectivity can be rationalised based on the energetics of these structures.
Chiral palladium(II) complexes possessing a tridentate N-heterocyclic carbene amidate alkoxide ligand: Access to oxygen-bridging dimer structures
Sakaguchi, Satoshi,Yoo, Kyung Soo,O'Neill, Justin,Lee, Joo Ho,Stewart, Timothy,Jung, Kyung Woon
supporting information; experimental part, p. 9326 - 9329 (2009/05/15)
(Chemical Equation Presented) Catalysts with a bite: Chiral PdII complexes were prepared with tridentate N-heterocyclic carbene amidate alkoxide ligands. Dimeric and monomeric forms were mutually convertible by acid or base treatment (see scheme). The catalysts promote asymmetric Heck reactions efficiently, offering high enantioselectivities far superior to those of existing methods.
Expedient synthesis of β,β-disubstituted α- methylenepropionates
Biswas, Kallolmay,B?rner, Christoph,Gimeno, Josepe,Goldsmith, Paul J.,Ramazzotti, Daniella,So, Angela L.K.,Woodward, Simon
, p. 1433 - 1442 (2007/10/03)
Baylis-Hillman alcohols are excellent sources of the allylic halides ArCHCH(CH2X)(CO2R) (X=Br, Cl; R1=Me, Et, But). The Z double bond isomers are attained in high isomeric purity (>14:1, Z/E). The halides are ch
