41725-90-0

Usage

Uses

Used in Flavor and Fragrance Industry:
Methyl 2-methyl-2-butenoate is used as a flavoring agent for its fruity odor, adding a pleasant aroma to various food products and beverages.
Used in Cosmetic Industry:
Methyl 2-methyl-2-butenoate is used as a fragrance ingredient in cosmetic products, providing a fresh and fruity scent.
Used in Organic Synthesis:
Methyl 2-methyl-2-butenoate is used as a reagent in organic synthesis, aiding in the production of various chemical compounds.
Used as a Solvent:
Methyl 2-methyl-2-butenoate is used as a solvent in various chemical processes, facilitating reactions and improving the efficiency of the synthesis.

InChI:InChI=1/C6H10O2/c1-4-5(2)6(7)8-3/h4H,1-3H3/b5-4+

Upstream product

• 67-56-1 methanol 
• 96-22-0 pentan-3-one 
• 157496-65-6 2-bromo-2-chloro-3-pentanone 

Downstream Products

• 868-57-5 methyl 2-methylbutanoate 
• 16096-33-6 1-phenyl-1H-indole 
• 765300-33-2 3-methyl-2-butenyl angelate 
• 65416-13-9 3Z-hexenyl tiglate 
• 847654-05-1 (+/-)-methyl 2-methylene-3-phenylbutanoate 
• 1202057-43-9 methyl 3-(4-acetylphenyl)-2-methylenebutanoate 
• 953786-91-9 (R)-3-(p-methoxyphenyl)-2-methylene-butyric acid methyl ester 
• 1202057-42-8 methyl 3-(4-(dimethylamino)phenyl)-2-methylenebutanoate 
• 1296172-83-2 methyl 2-hydroxyl-2-methyl-3-phenylbutanonate 

Relevant academic research and scientific papers

Iodine-mediated Z-selective oxidation of ketones to α,β- unsaturated esters: Synthesis and mechanistic studies

The Z-selective oxidation of simple acyclic ketones to Z-2,3-trisubstituted α,β-unsaturated esters is described. Enolates generated under the reaction conditions undergo double iodination followed by a Favorskii-related rearrangement to the unsaturated ester. This reaction represents the first stereoselective one-step transformation of ketones to α,β-unsaturated esters. Mechanistic studies suggest that an electrocyclic reaction governs the Favorskii-related rearrangement.

Asymmetric Aza-Wacker-Type Cyclization of N-Ts Hydrazine-Tethered Tetrasubstituted Olefins: Synthesis of Pyrazolines Bearing One Quaternary or Two Vicinal Stereocenters

We have developed an asymmetric aza-Wacker-type cyclization of N-Ts hydrazine-tethered tetrasubstituted olefins, affording optically active pyrazolines bearing chiral tetrasubstituted carbon stereocenters. This reaction is tolerant to a broad range of substrates under mild reaction conditions, giving the desired chiral products with high enantioselectivities. Generation of two vicinal stereocenters on the C=C double bonds was also achieved with high selectivities, a process which has been rarely studied for Wacker-type reactions. A mechanistic study revealed that this aza-Wacker-type cyclization undergoes a syn-aminopalladation process. It was also found that for substrates bearing two linear alkyl substituents on the outer carbon atom of the olefin, both of which are larger than a methyl group, the alkyl substituent that is cis to the intranucleophilic group participates more readily in β-hydride elimination. When one of the two alkyl substituents on the outer carbon atom of the olefin is a methyl group, β-hydride elimination proceeds selectively at the methylene side, thus both diastereomers can be prepared via switching the configuration of the olefin. Furthermore, the product can be converted to a pharmaceutical compound in high yields over three steps.

Synthesis of α,α-dialkoxy imines and α-keto acetals

A convenient synthesis of monoacetals of α-diones, i.e. α-keto acetals, was developed by silver ion induced alcoholysis of regiospecifically formed α-bromo-α-chloro ketones. Similarly, the corresponding α,α-dialkoxy ketimines were synthesized from silver ion induced alcoholysis of α-bromo-α-chloro ketimines. Both methods provide an easy access to protected forms of α-diones, useful as building blocks in organic chemistry.