84772-25-8 Usage
Uses
Used in Pharmaceutical Industry:
3-(3,4-DIMETHYL-PHENYL)-2-MERCAPTO-3H-QUINAZOLIN-4-ONE is used as a pharmaceutical agent for its anti-inflammatory and analgesic effects, making it a candidate for the development of medications aimed at treating pain and reducing inflammation.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 3-(3,4-DIMETHYL-PHENYL)-2-MERCAPTO-3H-QUINAZOLIN-4-ONE is utilized for its potential as an anti-cancer agent. Quinazolinone derivatives, similar to 3-(3,4-DIMETHYL-PHENYL)-2-MERCAPTO-3H-QUINAZOLIN-4-ONE, have shown promising anticancer activity, warranting further research and development for possible cancer treatments.
Used in Antimicrobial Applications:
3-(3,4-DIMETHYL-PHENYL)-2-MERCAPTO-3H-QUINAZOLIN-4-ONE is also considered for its antimicrobial properties, suggesting that it could be employed in the development of new antibiotics or antimicrobial agents to combat resistant strains of bacteria.
Used in Antioxidant Formulations:
Given its potential antioxidant activity, 3-(3,4-DIMETHYL-PHENYL)-2-MERCAPTO-3H-QUINAZOLIN-4-ONE may be used in the formulation of antioxidant therapies or supplements, which could be beneficial in the prevention and treatment of various diseases associated with oxidative stress.
Check Digit Verification of cas no
The CAS Registry Mumber 84772-25-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,7,7 and 2 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 84772-25:
(7*8)+(6*4)+(5*7)+(4*7)+(3*2)+(2*2)+(1*5)=158
158 % 10 = 8
So 84772-25-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H14N2OS/c1-10-7-8-12(9-11(10)2)18-15(19)13-5-3-4-6-14(13)17-16(18)20/h3-9H,1-2H3,(H,17,20)
84772-25-8Relevant academic research and scientific papers
Synthesis and Anticonvulsant Activity Evaluation of 4-Phenyl-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one and Its Derivatives
Zhang, Hong-Jian,Jin, Peng,Wang, Shi-Ben,Li, Fu-Nan,Guan, Li-Ping,Quan, Zhe-Shan
, p. 564 - 574 (2015/08/06)
A series of 4-(substituted-phenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-ones (6a-x) with triazole and other heterocyclic substituents (7-14) were synthesized and the compounds were evaluated for their anticonvulsant activity and neurotoxicity by maximal electroshock (MES) and rotarod neurotoxicity tests. Among the compounds studied, 6o and 6q showed wide margins of safety with protective indices (PIs) that were much higher than those of currently used drugs (PI6o > 25.5, PI6q > 26.0). Compounds 6o and 6q showed significant oral activity against MES-induced seizures in mice, with ED50 values of 88.02 and 94.6 mg/kg, respectively. The two compounds were also found to have potent activity against seizures that were induced by pentylenetetrazole and bicuculline. A series of 4-(substituted-phenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-ones with triazole and other heterocyclic substituents were synthesized and the compounds were evaluated for their anticonvulsant activity and neurotoxicity using maximal electroshock and rotarod neurotoxicity tests.
