67117-00-4 Usage
Uses
Used in Pharmaceutical Industry:
2,4(1H,3H)-Quinazolinedione, 3-(3,4-dimethylphenyl)is used as a PDE4 inhibitor for its potential therapeutic applications in the treatment of inflammatory and respiratory conditions. PDE4 inhibitors have been shown to modulate inflammatory processes by reducing the production of pro-inflammatory mediators, making them promising candidates for conditions such as asthma, chronic obstructive pulmonary disease (COPD), and inflammatory bowel disease.
Used in Neuroprotective Applications:
2,4(1H,3H)-Quinazolinedione, 3-(3,4-dimethylphenyl)is used as a neuroprotective agent for its potential to protect neurons from damage and degeneration. PDE4 inhibitors have been shown to modulate intracellular signaling pathways involved in neuronal survival and synaptic plasticity, making them promising candidates for the treatment of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis.
Used in Drug Discovery and Development:
2,4(1H,3H)-Quinazolinedione, 3-(3,4-dimethylphenyl)is used as a novel drug candidate in the field of drug discovery and development. Its unique chemical structure and PDE4 inhibitory activity make it a valuable compound for further research and optimization to develop more effective and selective therapeutic agents for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 67117-00-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,1,1 and 7 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 67117-00:
(7*6)+(6*7)+(5*1)+(4*1)+(3*7)+(2*0)+(1*0)=114
114 % 10 = 4
So 67117-00-4 is a valid CAS Registry Number.
67117-00-4Relevant academic research and scientific papers
Relationships between the chemical structure of substances and their antimycobacterial activity against atypical strains. Part 18. 3-phenyl-2H-1,3-benzoxazine-2,4(3H)-diones and isosteric 3-phenylquinazoline-2,4(1H,3H)-diones
Waisser, Karel,Machacek, Milos,Dostal, Hynek,Gregor, Jiri,Kubicova, Lenka,Klimesova, Vera,Kunes, Jiri,Palat Jr., Karel,Hladuvkova, Jana,Kaustova, Jarmila,Moellmann, Ute
, p. 1902 - 1924 (2007/10/03)
A series of 3-phenyl-2H-1,3-benzoxazine-2,4(3H)-diones 2 and 3-phenylquinazoline-2,4(1H,3H)-diones 5 substituted on the phenyl rings were synthesized. The target compounds as well as the intermediates were tested against Mycobacterium tuberculosis, M. kansasii, and M. avium. The replacement of the oxygen atom by nitrogen resulted in a decrease or loss of antimycobacterial activity. 2-[(Ethoxycarbonyl)amino]benzanilides 4 appeared to be inactive. Salicylanilides 1 and 3-phenyl-2H-1,3-benzoxazine-2,4(3H)-diones 2 exhibit significant activity against both M. tuberculosis and nontuberculous mycobacteria (the MICs within the range of 4-250 μmol/l for all compounds). The antimycobacterial activity of the compounds increases with increasing both electron-withdrawing properties and hydrophobicity of the substituent(s) on the phenyl moiety. The antimycobacterial profile of the compounds was analyzed according to the criteria based on vector algebra, such as cosine coefficients. Moreover, salicylanilides 1 exhibit activity against other microorganisms tested by the agar diffusion method.
