847729-63-9

Basic information

• Product Name: (S)-tert-butyl 1-(4-cyanophenyl)ethylcarbaMate
• Synonyms: (S)-tert-butyl 1-(4-cyanophenyl)ethylcarbaMate
• CAS NO: 847729-63-9
• Molecular Formula: C₁₄H₁₈N₂O₂
• Molecular Weight: 246.30492
• Mol File: 847729-63-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 394.1±35.0 °C(Predicted)
• Appearance: /
• Density: 1.08±0.1 g/cm3(Predicted)
• PKA: 11.83±0.46(Predicted)
• CAS DataBase Reference: (S)-tert-butyl 1-(4-cyanophenyl)ethylcarbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tert-butyl 1-(4-cyanophenyl)ethylcarbaMate(847729-63-9)
• EPA Substance Registry System: (S)-tert-butyl 1-(4-cyanophenyl)ethylcarbaMate(847729-63-9)

Safety Data

• Hazardous Substances Data: 847729-63-9(Hazardous Substances Data)

Usage

General Description

(S)-tert-butyl 1-(4-cyanophenyl)ethylcarbaMate is a chemical compound with the molecular formula C16H22N2O2, which is commonly used as a chiral auxiliary in organic synthesis. It is a white solid that is sparingly soluble in water and is often used as a reagent in asymmetric synthesis to introduce chirality into molecules. (S)-tert-butyl 1-(4-cyanophenyl)ethylcarbaMate is also known for its ability to act as a protecting group for alcohols, amines, and carboxylic acids, allowing for selective reactions in complex synthesis pathways. Additionally, (S)-tert-butyl 1-(4-cyanophenyl)ethylcarbaMate has been studied for its potential use in pharmaceutical applications due to its unique chiral properties and ability to influence the stereochemistry of organic reactions.

Upstream product

• 773837-37-9 sodium cyanide 
• 1313367-04-2 [(S)-1-(4-Iodo-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 557-21-1 zinc(II) cyanide 
• 847728-89-6 (S)-tert-butyl (1-(4-bromophenyl)ethyl)carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 557-21-1 dicyanozinc 

Downstream Products

• 847729-65-1 [(1S)-1-(4-(2H-tetrazol-5-yl)phenyl)ethyl]amine hydrochloride 
• 1177316-44-7 (S)-4-(1-aminoethyl)benzonitrile hydrochloride 
• 1177316-44-7 (S)-4-(1-aminoethyl)benzonitrile hydrochloride 
• 36244-70-9 (S)-4-(1-aminoethyl)benzonitrile 
• 1097196-64-9 tert-butyl [(1S)-1-{4-[amino(hydroxyimino)methyl]phenyl}ethyl]carbamate 
• 847729-64-0 tert-butyl [(1S)-1-(4-(2H-tetrazol-5-yl)phenyl)ethyl]carbamate 
• 916211-64-8 (S)-4-(1-aminoethyl)benzoic acid hydrochloride salt 

Relevant articles and documents

BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE

The present disclosure relates to bifunctional compounds, which find utility as modulators of SMARCA2 or BRM (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand that binds to the Von Hippel-Lindau E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

METALLOPROTEASE INHIBITORS

The present invention relates to amide containing aromatic MMP inhibiting compounds with a mono-amide heteroaromatic group, of formulas I and II:

Substituted bis-amide metalloprotease inhibitors

This invention relates to substituted bis-amide pyrimidine compounds of Formula (I), which are useful for the treatment of metalloprotease mediated diseases, in particular MMP-13 related diseases.