36244-70-9

Usage

Uses

Used in Pharmaceutical Industry:
(S)-1-(4-CYANOPHENYL)ETHANAMINE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with specific therapeutic properties.
Used in Organic Compounds Synthesis:
In the field of organic chemistry, (S)-1-(4-CYANOPHENYL)ETHANAMINE serves as a building block, facilitating the creation of a wide range of organic compounds with diverse applications.
Used in Material Production:
(S)-1-(4-CYANOPHENYL)ETHANAMINE is utilized as a component in the production of various materials, leveraging its chemical properties to enhance the characteristics of the end products.
Used in Medicinal and Biochemical Research:
Due to its unique structural properties and reactivity, (S)-1-(4-CYANOPHENYL)ETHANAMINE is employed in research settings to explore its potential in the development of new biochemical pathways and medicinal applications.

Upstream product

• 199441-99-1 (S)-N-ethanoyl-1-(4-cyanophenyl)ethylamine 
• 27298-97-1 (S)-1-(4-bromophenyl)ethylamine 
• 186296-23-1 (S)-N-(1-(4-bromophenyl)ethyl)acetamide 
• 847729-63-9 tert-butyl N-[(1S)-1-(4-cyanophenyl)ethyl]carbamate 
• 1443-80-7 4-cyanophenyl methyl ketone 

Downstream Products

• 222714-30-9 (S)-N-2-chloroethanoyl-(4-cyanophenyl)ethylamine 
• 1268351-04-7 C₂₆H₂₂F₃N₃O 
• 1362627-43-7 C₂₃H₂₉N₃O₃ 
• 1355158-57-4 methyl N-[(1S)-1-(4-cyanophenyl)ethyl]-D-alaninate 
• 1355158-58-5 methyl N-[(1S)-1-(4-cyanophenyl)ethyl]-L-alaninate 

Relevant academic research and scientific papers

Widely applicable background depletion step enables transaminase evolution through solid-phase screening

Directed evolution of transaminases is a widespread technique in the development of highly sought-after biocatalysts for industrial applications. This process, however, is challenged by the limited availability of effective high-throughput protocols to evaluate mutant libraries. Here we report a rapid, reliable, and widely applicable background depletion method for solid-phase screening of transaminase variants, which was successfully applied to a transaminase from Halomonas elongata (HEWT), evolved through rounds of random mutagenesis towards a series of diverse prochiral ketones. This approach enabled the identification of transaminase variants in viable cells with significantly improved activity towards para-substituted acetophenones (up to 60-fold), as well as tetrahydrothiophen-3-one and related substrates. Rationalisation of the mutants was assisted by determination of the high-resolution wild-type HEWT crystal structure presented herein.

A novel series of potent and selective EP4 receptor ligands: Facile modulation of agonism and antagonism

A novel series of EP4 ligands, based on a benzyl indoline scaffold, has been discovered. It was found that agonism and antagonism in this series can be easily modulated by minor modifications on the benzyl group. The pharmacokinetic, metabolic

Synthesis, time-resolved luminescence, nmr spectroscopy, circular dichroism and circularly polarised luminescence studies of enantiopure macrocyclic lanthanide tetraamide complexes

The syntheses and properties of a series of lanthanide complexes (Ln = Eu, Tb, Dy, Yb) of C4 symmetric chiral tetraamide ligands based on 1,4,7,10- tetraazacyclododecane are reported. The configuration of the chiral centre at carbon in the amid