847736-94-1

Basic information

• Product Name: C₂₅H₂₈FNO₃
• CAS NO: 847736-94-1
• Molecular Weight: 409.501
• Mol File: 847736-94-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₈FNO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₈FNO₃(847736-94-1)
• EPA Substance Registry System: C₂₅H₂₈FNO₃(847736-94-1)

Safety Data

• Hazardous Substances Data: 847736-94-1(Hazardous Substances Data)

Upstream product

• 156868-83-6 3-(3-fluorophenyl)propan-1-ol 
• 32263-70-0 6-benzyloxy-3,4-dihydro-2H-naphthalen-1-one 
• 3470-50-6 6-Hydroxy-1-tetralone 
• 458-45-7 3-(3-fluorophenyl)propionic acid 
• 1355088-68-4 C₂₁H₂₁FO₂ 
• 36476-78-5 3-azetidinecarboxylic acid 
• 847585-92-6 6-hydroxy-1-methyl-3,4-dihydro-naphthalene-2-carbaldehyde 
• 847585-91-5 6-(benzyloxy)-1-methyl-3,4-dihydronaphthalene-2-carbaldehyde 
• 847585-90-4 7-(benzyloxy)-4-methyl-1,2-dihydronaphthalene 

Downstream Products

• 847585-23-3 1-({6-[3-(3-fluorophenyl)propoxy]-1-methyl-3,4-dihydro-2-naphthalenyl}methyl)-3-azetidinecarboxylic acid hydrochloride 

Relevant articles and documents

Structure-activity relationship studies of S1P agonists with a dihydronaphthalene scaffold

Structure-activity relationship (SAR) of sphingosine-1-phosphate receptor agonists with a dihydronaphthalene scaffold was investigated. Compound 1 was modified to improve S1P1 agonistic activity and in vivo peripheral lymphocyte lowering (PLL) activity without impairing selectivity over S1P 3 agonistic activity. A detailed SAR study of the terminal lipophilic part revealed that the introduction of substituents on the propylene linker and the terminal benzene ring influences in vitro and PLL activities. Compound 6n bearing a (S)-methyl group at the 2-position on the propylene linker and chlorine at the para-position on the terminal benzene ring showed potent hS1P1 agonistic activity with excellent selectivity over hS1P 3 and in vivo PLL activity in mice.