84774-19-6

Upstream product

• 84718-98-9 5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl O-methyl phosphate 
• 42926-80-7 5'-O-(4-monomethoxytrityl)-2'-deoxythymidine 
• 13084-61-2 3'-O-(4-methoxytriphenylmethyl)thymidine 
• 90662-75-2 pyridinium 5'-O-monomethoxytritylthymidine 3'-phosphoranilidate 

Relevant academic research and scientific papers

2'-DEOXYRIBONUCLEOSIDE 3'-ARYL PHOSPHORANILIDATES KEY INTERMEDIATES IN THE STEREOSPECIFIC SYNTHESIS OF 2'-DEOXYRIBONUCLEOSIDE CYCLIC 3',5'-PHOSPHOROTHIOATES AND DINUCLEOSIDE(3'->5')-PHOSPHOROTHIOATES

Phosphorylation of the 5'-O-monomethoxytrityl-2'-deoxyribonucleosides by means of aryl phosphoranilidochloridates gives the diastereomers of 5'-O-monomethoxytrityl-2'-deoxyribonucleoside 3'-aryl phosphoranilidates.Their separation can be performed by mean

THE CHEMICAL SYNTHESIS OF THE Rp AND Sp DIASTEREOMERS OF THYMIDYL-(3'-5')THYMIDYL O,O-PHOSPHOROTHIOATE

The synthesis and separation of diastereomers of protected thymidyl-(3'-5')thymidyl O,O-phosphoranilidate (4) allowed to obtain in the stereospecific manner title compounds 5, whose absulute configuration at P atom was assigned enzymatically.TP(S)T diastereomers (5) were obtained independently via "phosphite" procedure.